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Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
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安全信息

H3160

Sigma-Aldrich

氢化可的松

meets USP testing specifications

别名:

11β,17α,21-三羟基孕酮-4-烯-3,20-二酮, 17-羟基皮质酮标准液, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 皮质醇标准液, 肯德尔氏化合物F, 赖希斯坦氏物质M

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About This Item

经验公式（希尔记法）:
C21H30O5
CAS号:
50-23-7
分子量:
362.46
Beilstein:
1354819
EC 号:
200-020-1
MDL编号:
MFCD00011654
UNSPSC代码:
51111800
PubChem化学物质编号:
24895560
NACRES:
NA.21
价格与库存信息目前不能提供

生物来源

plant (wild yam)

质量水平

300

Agency

USP/NF
meets USP testing specifications

方案

97.0-102.0% dry basis

表单

powder

效能

0.004-0.005 μg/mL

mp

211-214 °C (lit.)

溶解性

water: soluble 0.28 g/L at 25 °C

应用

pharmaceutical (small molecule)

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

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此商品
PHR1014H0135H0888
Hydrocortisone meets USP testing specifications

H3160

Hydrocortisone

Hydrocortisone Pharmaceutical Secondary Standard; Certified Reference Material

PHR1014

Hydrocortisone

Hydrocortisone γ-irradiated, powder, BioXtra, suitable for cell culture

H0135

Hydrocortisone

Hydrocortisone BioReagent, suitable for cell culture

H0888

Hydrocortisone

biological source

plant (wild yam)

biological source

-

biological source

synthetic (organic)

biological source

-

assay

97.0-102.0% dry basis

assay

-

assay

≥80% (HPLC)

assay

≥98%

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

form

powder

form

-

form

powder

form

powder

solubility

water: soluble 0.28 g/L at 25 °C

solubility

-

solubility

ethanol: 1 mg/mL, clear

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow

应用


  • Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: This research presents a novel method for embedding hydrocortisone into bacterial cellulose using microemulsion systems, highlighting its potential for creating anti-inflammatory wound dressings, a significant advancement in pharmaceutical design and material science (Zahel et al., 2024).

  • Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis: This review discusses the role of hydrocortisone in treating chronic fatigue syndrome by modulating the hypothalamus-pituitary-adrenal axis, providing a comprehensive overview of its therapeutic applications in endocrinology (Zhang and Wang, 2024).

生化/生理作用

肾上腺皮质分泌的原始糖皮质激素。
肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍，但 Na2+ 保留效力要低得多。

外形

室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360Df,H373

危险分类

Repr. 1A - STOT RE 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000421092
    0000403299
    0000403299
    0000421092
    0000397507

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    Liselotte van Bloemendaal et al.
    Diabetes, 63(12), 4186-4196 (2014-07-30)
    Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in
    K J Rademaker et al.
    Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
    The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects
    Florian Hardeveld et al.
    Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
    Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
    Lorenz Goette et al.
    Psychoneuroendocrinology, 54, 115-123 (2015-02-24)
    Social competition is a fundamental mechanism of evolution and plays a central role in structuring individual interactions and communities. Little is known about the factors that affect individuals' competitive success, particularly in humans. Key factors might include stress, a major
    Lex W Doyle et al.
    Neonatology, 98(2), 111-117 (2010-02-13)
    Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants.
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