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Merck
CN

47619

Sigma-Aldrich

Fmoc-Ser(tBu)-OH

≥98.0% (HPLC), for peptide synthesis

Synonym(s):

Fmoc-O-tert-butyl-L-serine

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¥1,808.60
5 G
¥6,324.87

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1 G
¥1,808.60
5 G
¥6,324.87

About This Item

Empirical Formula (Hill Notation):
C22H25NO5
CAS Number:
Molecular Weight:
383.44
Beilstein:
3632013
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

¥1,808.60


Please contact Customer Service for Availability
New, lower price on this item!

Request a Bulk Order

Product Name

Fmoc-Ser(tBu)-OH, ≥98.0% (HPLC)

Quality Level

Assay

≥98.0% (HPLC)

form

powder

optical activity

[α]20/D +25.5±1°, c = 1% in ethyl acetate

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

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This Item
H9039MBD00523741
biological source

Porcine

biological source

bovine

biological source

-

biological source

-

assay

≥96.0% (HPLC)

assay

≥90%

assay

-

assay

-

technique(s)

tissue culture: suitable, transfection: suitable

technique(s)

toxicology assay: suitable

technique(s)

-

technique(s)

-

form

powder or crystals

form

powder

form

liquid

form

solid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

15-25°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

Application

Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis.[1] Some of the reported examples are:
  • Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.[2]
  • Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.[3]
  • Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.[4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Self?Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per?Glycosylated MUC1 Glycopeptides and the Toll?like Receptor 2 Agonist Pam3CysSer.
Wilkinson B L, et al.
Angewandte Chemie (International Edition in English), 50(7), 1635-1639 (2011)
Chemical synthesis of ubiquitin, ubiquitin?based probes, and diubiquitin.
El Oualid F, et al.
Angewandte Chemie (International Edition in English), 49(52), 10149-10153 (2010)
Advances in proline ligation.
Townsend S D, et al.
Journal of the American Chemical Society, 134(8), 3912-3916 (2012)
Total synthesis of daptomycin by cyclization via a chemoselective serine ligation.
Lam H Y, et al.
Journal of the American Chemical Society, 135(16), 6272-6279 (2013)
R Ashton Lavoie et al.
Biotechnology and bioengineering, 117(2), 438-452 (2019-10-28)
The clearance of host cell proteins (HCPs) is of crucial importance in biomanufacturing, given their diversity in composition, structure, abundance, and occasional structural homology with the product. The current approach to HCP clearance in the manufacturing of monoclonal antibodies (mAbs)

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