47561
芴甲氧羰酰-色氨酸
≥97.0% (HPLC), for peptide synthesis
别名:
Nα-芴甲氧羰基-N(in)-叔丁氧羰基-L-色氨酸, N(in)-Boc-Nα-Fmoc-L-色氨酸
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关于此项目
经验公式（希尔记法）:
C31H30N2O6
化学文摘社编号:
分子量:
526.58
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Beilstein/REAXYS Number:
7698009
MDL number:
产品名称
芴甲氧羰酰-色氨酸, ≥97.0% (HPLC)
SMILES string
CC(C)(C)OC(=O)n1cc(C[C@H](NC(=O)OCC2c3ccccc3-c4ccccc24)C(O)=O)c5ccccc15
InChI key
ADOHASQZJSJZBT-SANMLTNESA-N
InChI
1S/C31H30N2O6/c1-31(2,3)39-30(37)33-17-19(20-10-8-9-15-27(20)33)16-26(28(34)35)32-29(36)38-18-25-23-13-6-4-11-21(23)22-12-5-7-14-24(22)25/h4-15,17,25-26H,16,18H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1
assay
≥97.0% (HPLC)
form
solid
optical activity
[α]20/D −21±2°, c = 1% in DMF
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
application(s)
peptide synthesis
functional group
Boc
Fmoc
storage temp.
2-8°C
Quality Level
Application
芴甲氧羰酰-色氨酸(叔丁氧羰酰）可用于合成治疗2型糖尿病的胰高血糖素样肽1(GLP-1)类似物和通过芴甲氧羰酰(Fmoc)固相多肽合成(SPPS)各种多肽。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Limiting racemization and aspartimide formation in microwave-enhanced Fmoc solid phase peptide synthesis.
Palasek SA, et al.
Journal of Peptide Science, 13(3), 143-148 (2007)
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.
Knudsen LB, et al.
Journal of Medicinal Chemistry, 43(9), 1664-1669 (2000)
Taru Dube et al.
Amino acids, 49(5), 975-993 (2017-03-12)
Surging reports of peptide-based nanosystems and their growing potency in terms of biological utility demand for the search of newer and simpler peptide-based systems that could serve as smart templates for the development of self-assembled nanostructures. Use of simple amino
Stimuli-Responsive Codelivery of Oligonucleotides and Drugs by Self-Assembled Peptide Nanoparticles.
Severin J Sigg et al.
Biomacromolecules, 17(3), 935-945 (2016-02-13)
Ever more emerging combined treatments exploiting synergistic effects of drug combinations demand smart, responsive codelivery carriers to reveal their full potential. In this study, a multifunctional stimuli-responsive amphiphilic peptide was designed and synthesized to self-assemble into nanoparticles capable of co-bearing
Shabnam Tarvirdipour et al.
Soft matter, 16(6), 1678-1691 (2020-01-23)
To overcome the low efficiency and cytotoxicity associated with most non-viral DNA delivery systems we developed a purely peptidic self-assembling system that is able to entrap single- and double-stranded DNA of up to 100 nucleotides in length. (HR)3gT peptide design
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