47622
Fmoc-Thr(tBu)-OH
≥98.0% (HPLC), for peptide synthesis
别名:
Fmoc-O-叔丁基-L-苏氨酸
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关于此项目
经验公式（希尔记法）:
C23H27NO5
化学文摘社编号:
分子量:
397.46
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
276-261-1
MDL number:
Beilstein/REAXYS Number:
4581133
产品名称
Fmoc-Thr(tBu)-OH, ≥98.0% (HPLC)
SMILES string
C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
InChI key
LZOLWEQBVPVDPR-VLIAUNLRSA-N
InChI
1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/t14-,20+/m1/s1
assay
≥98.0% (HPLC)
optical activity
[α]20/D +16±1°, c = 1% in ethyl acetate
reaction suitability
reaction type: C-H Activation
reaction type: Fmoc solid-phase peptide synthesis
reagent type: ligand
reaction type: Peptide Synthesis
application(s)
peptide synthesis
functional group
Fmoc
amine
carboxylic acid
storage temp.
2-8°C
Quality Level
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Application
Fmoc-Thr(tBu)-OH可用于通过固相多肽合成反应合成chlorofusin类似物。此外，在复杂的缩酚酸肽(depsipeptide)固相合成中，可作为胺和羟基的保护基。
General description
Fmoc-Thr(tBu)-OH也称为Fmoc-O-叔丁基-L-苏氨酸，常用作多肽合成中的氨基酸合成砌块。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
General Fmoc-Based Solid-Phase Synthesis of Complex Depsipeptides Circumventing Problematic Fmoc Removal
A Lobo-Ruiz
European Journal of Organic Chemistry, 2020, 183-192 (2020)
Solid-phase synthesis of chlorofusin analogues
ECY Woon
The Journal of Organic Chemistry, 72, 5146-5151 (2007)
Gizella Csire et al.
Journal of inorganic biochemistry, 203, 110927-110927 (2019-12-07)
Interaction of copper(II) and nickel(II) ions with the Ac-PHAAAGTHSMKHM-NH2 tridecapeptide containing the His85, His96 and His111 binding sites of human prion protein has been studied by various techniques. pH-potentiometry, UV-Vis and circular dichroism spectroscopy were applied to study the stoichiometry
Zdenek Kukacka et al.
ChemMedChem, 13(9), 909-915 (2018-02-24)
α-Galactosidase (αGal) is a lysosomal enzyme that hydrolyses the terminal α-galactosyl moiety from glycosphingolipids. Mutations in the encoding genes for αGal lead to defective or misfolded enzyme, which results in substrate accumulation and subsequent organ dysfunction. The metabolic disease caused
Stefan Eissler et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(10), 757-762 (2017-06-22)
In solid-phase peptide synthesis, the nominal batch size is calculated using the starting resin substitution and the mass of the starting resin. The starting resin substitution constitutes the basis for the calculation of a whole set of important process parameters
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