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Merck
CN
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文件

51280

Sigma-Aldrich

氯化高铁血红素

BioXtra, from Porcine, ≥96.0% (HPLC)

别名:

氯(原卟啉酸)铁(III), 氯化血红素, 氯原卟啉IX铁(III), 高铁原卟啉IX氯, 高铁血红素（氯）

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About This Item

经验公式（希尔记法）:
C34H32ClFeN4O4
CAS号:
16009-13-5
分子量:
651.94
Beilstein:
5229914
EC 号:
240-140-1
MDL编号:
MFCD00010726
UNSPSC代码:
12352202
PubChem化学物质编号:
57651319
NACRES:
NA.79

生物来源

Porcine

质量水平

200

产品线

BioXtra

检测方案

≥96.0% (HPLC)

形式

powder or crystals

技术

tissue culture: suitable
transfection: suitable

储存温度

2-8°C

SMILES字符串

Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Fe](Cl)n34)c(C=C)c5C

InChI

1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

InChI key

BTIJJDXEELBZFS-HXFTUNQESA-K

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相关类别

应用

高铁血红素应用于以下应用中：
  • 研究菌株和生长条件
  • 用于短期菌落测定(培养基由血红素和其他成分组成)
  • 细胞转染
它可用于分析MMV(抗疟药物)疟疾盒化合物对β-血红蛋白形成的抑制作用。

生化/生理作用

高铁血红素是经氧化血红素，是一系列蛋白质的一种含铁的辅基基团。游离血红素在溶血后从血红蛋白中释放出来，具有促炎作用，有助于铁源活性氧的生成。游离血红素水平可在各种病理条件下上调，并可导致各种炎症条件，包括血管疾病、肾功能衰竭和免疫介导的疾病。

高铁血红素可用于研究血红素加氧酶1 (HO-1)的表达和抑制以及HO-1的活性。 血凝素是生长流感嗜血杆菌所必需的“X因子”。

相关产品

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说明
价格

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Product 51280, Hemin?

    Hemin can be dissolved in DMSO at 1 mM. This product should be soluble in 1.4 M ammonium hydroxide (50 mg/ml) with 5 minutes of heating at 95 °C, yielding a dark brown solution.  A stock solution of 0.25% hemin in 50% triethanolamine can be made.

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  5. What is the Department of Transportation shipping information for this product?

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