NOTCH2
notch 2
别名:
AGS2, HJCYS, hN2
物种:
Human NOTCH2 (4853), Mouse Notch2 (18129), Rat Notch2 (29492), cow NOTCH2 (513730), sheep NOTCH2 (101112098), domestic cat NOTCH2 (101091800), Horse NOTCH2 (100067078), dog NOTCH2 (483148), chicken NOTCH2 (374031), Zebrafish notch2 (58065) ...展开
UniProtKB ID:
基因ID:
- Human(4853) Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
- Mouse(18129) notch 2
- Rat(29492) notch 2
- cow(513730) notch 2
- sheep(101112098) notch 2
- domestic cat(101091800) notch 2
- Horse(100067078) notch 2
- dog(483148) notch 2
- chicken(374031) notch 2
- Zebrafish(58065) notch homolog 2
- domestic guinea pig(100715372) notch 2
- naked mole-rat(101712759) notch 2
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ELISA
货号
说明
物种
Antibodies
货号
说明
物种反应性
应用
抗-NOTCH2 (Cleaved-Val1697) 兔抗, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
western blot
Anti-Notch 2 Antibody, NT, serum, from rabbit,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-NOTCH2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-NOTCH2 (Cleaved-Ala1734) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
western blot
Anti-NOTCH2 (Cleaved-Asp1733) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
货号
说明
物种
Notch-2/Fc Chimera from rat, recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder,
物种
rat
esiRNA
货号
说明
物种