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Merck
CN

HLA-C

major histocompatibility complex, class I, C

别名:
D6S204, HLA-JY3, HLC-C, PSORS1
物种:
Human HLA-C (3107)
UniProtKB ID:
P10321, O78061, O78083, Q29631, Q29652, Q29867, Q29990, Q95463
基因ID:
  • Human(3107) Summary: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

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Antibodies

货号
说明
物种反应性
应用
MABF233
Anti-HLA-C Antibody, clone DT9, clone DT9, from mouse,
物种反应性
human
应用
flow cytometry
immunoprecipitation (IP)
SAB1405938
Anti-HLA-C antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
SAB2107752
Anti-HLA-C antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, pig, rabbit
应用
western blot
MABN1783
抗HLA I类抗原抗体，克隆W6 / 32, clone W6/32, from mouse,
物种反应性
human
应用
affinity binding assay
affinity chromatography
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
neutralization
H1650
抗HLA I类抗原单克隆抗体 小鼠抗, clone W6/32, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, monkey
应用
flow cytometry
immunofluorescence
immunoprecipitation (IP)