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Merck
CN

BRD2

bromodomain containing 2

别名:
D6S113E, FSH, FSRG1, NAT, RING3, RNF3
物种:
Human BRD2 (6046), Mouse Brd2 (14312), Rat Brd2 (294276), domestic guinea pig Brd2 (100734555), cow BRD2 (505358), Domestic Rabbit BRD2 (100343906), domestic cat BRD2 (101084362), sheep BRD2 (101110276), chicken BRD2 (417049), dog BRD2 (474868)
UniProtKB ID:
P25440, A2AAU0, B0S7P0, B1AZT1, O00699, O00700, Q15310, Q5STC9
基因ID:
  • Human(6046) Summary: This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
  • Mouse(14312) bromodomain containing 2
  • Rat(294276) bromodomain containing 2
  • domestic guinea pig(100734555) bromodomain containing 2
  • cow(505358) bromodomain containing 2
  • Domestic Rabbit(100343906) bromodomain containing 2
  • domestic cat(101084362) bromodomain containing 2
  • sheep(101110276) bromodomain containing 2
  • chicken(417049) bromodomain containing 2
  • dog(474868) bromodomain containing 2
  • naked mole-rat(101699681) bromodomain containing 2

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Antibodies

货号
说明
物种反应性
应用
HPA074612
Anti-Brd2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
WH0006046M1
Monoclonal Anti-BRD2 antibody produced in mouse, clone 3D10, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
HPA042816
Anti-BRD2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
PLA0261
Rabbit anti-BRD2 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
物种反应性
human, mouse
应用
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
ABE477
Anti-BRD2 Antibody, from rabbit, purified by affinity chromatography,
物种反应性
human, rat
应用
immunohistochemistry
western blot

Small Molecule - Inhibitor

货号
说明
物种
SML1272
I-BET762, ≥98% (HPLC),
物种
human
SML1605
OTX015, ≥98% (HPLC),
物种
human

Proteins

货号
说明
物种
SRP0454
BRD2, BD1, BD2 (65-459) GST tag human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
物种
human
SRP0450
BRD2 (339-459) His tag human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
物种
human
SRP0451
BRD2 (65-187) GST tag human, recombinant, expressed in E. coli, ≥81% (SDS-PAGE),
物种
human
SRP0452
BRD2 (65-187) His tag human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
物种
human
SRP0453
BRD2 (339-459) GST tag human, recombinant, expressed in E. coli, ≥86% (SDS-PAGE),
物种
human

esiRNA

货号
说明
物种
EMU067621
MISSION® esiRNA, targeting mouse Brd2,
物种
mouse
EHU108021
MISSION® esiRNA, targeting human BRD2,
物种
human