AXIN2
axin 2
别名:
AXIL, ODCRCS
物种:
Human AXIN2 (8313), Mouse Axin2 (12006), Rat Axin2 (29134), Zebrafish axin2 (58080), naked mole-rat Axin2 (101716964), domestic guinea pig Axin2 (100731715), sheep AXIN2 (101109815), cow AXIN2 (511619), domestic cat AXIN2 (101093061), dog AXIN2 (490903)
UniProtKB ID:
基因ID:
- Human(8313) Summary: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
- Mouse(12006) axin2
- Rat(29134) axin 2
- Zebrafish(58080) axin 2 (conductin, axil)
- naked mole-rat(101716964) axin 2
- domestic guinea pig(100731715) axin 2
- sheep(101109815) axin 2
- cow(511619) axin 2
- domestic cat(101093061) axin 2
- dog(490903) axin 2
- chicken(395152) axin 2
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Antibodies
货号
说明
物种反应性
应用
Anti-Axin2, clone cond4-1D5 Antibody, clone cond4-1D5, from rat,
物种反应性
human
应用
immunocytochemistry
western blot
western blot
Anti-AXIN2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-AXIN2 antibody produced in mouse, clone 3B6, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
esiRNA
货号
说明
物种