产品名称
Anti-Axin2, clone cond4-1D5 Antibody, clone cond4-1D5, from rat
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
cond4-1D5, monoclonal
species reactivity
human
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AXIN2(8313)
Analysis Note
Evaluated by Western Blotting in HCT116 cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected Axin2 in 10 µg of HCT116 cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected Axin2 in 10 µg of HCT116 cell lysate.
Application
Immunocytochemistry Analysis: 20 μg/mL of this antibody from a representative lot detected Axin2 in HeLa, HEK293 and NIH-3T3 cells.
Western Blotting Analysis: A representative lot of this antibody detected Axin2 in SW 480 cell lines
Western Blotting Analysis: A representative lot of this antibody detected Axin2 in SW 480 cell lines
Research Category
Signaling
Apoptosis & Cancer
Signaling
Apoptosis & Cancer
Research Sub Category
General Post-translation Modification
General Post-translation Modification
This Anti-Axin2, clone cond4-1D5 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of Axin2.
Biochem/physiol Actions
This monoclonal antibody recognizes both endogeneous and overexpressed Axin2 and does not cross-react with Axin1
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Axin-2, or Axis inhibition protein 2, is an inhibitor of the Wnt signaling pathway that down-regulates beta-catenin and APC through phosphorylation. Axin-2 abnormalities are linked to defective mismatch repair and have been found to be involved in colorectal cancer (CRC) and oligodontia-colorectal cancer syndrome (ODCRCS). Axin-2 can be found in brain and lymphoblast tissues.
~ 95 kDa observed
Immunogen
Linear peptide corresponding to Human Axin 2.
Other Notes
Concentration: Please refer to lot specific datasheet.
Physical form
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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