SAB6012051
Anti Axin 2 Antibody, clone 23GB1545, Rabbit Monoclonal
clone 23GB1545, recombinant rabbit monoclonal, expressed in HEK293 cells
别名:
Axin2, Conductin
产品名称
Anti Axin 2 Antibody, clone 23GB1545, Rabbit Monoclonal, clone 23GB1545, recombinant rabbit monoclonal, expressed in HEK293 cells
biological source
rabbit (Monoclonal)
recombinant
expressed in HEK 293 cells
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
23GB1545, recombinant monoclonal
form
buffered aqueous glycerol solution
mol wt
94 kDa
species reactivity
rat, human
packaging
vial of 1.5 mL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
Quality Level
Gene Information
human ... AXIN2(8313)
sustainability
Greener Alternative Product
concentration
3 mg/ml
technique(s)
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000
isotype
IgG
Ensembl | human accession no.
NCBI accession no.
UniProt accession no.
greener alternative category
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Other Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Physical form
Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
General description
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
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Immunogen
A synthesized peptide corresponding to a sequence within amino acids 58-93 of human Axin2 [NP_004646.3].
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