HPLC Analysis of Sibutramine Enantiomers on Astec^® CHIROBIOTIC^® V

材料

分析色谱柱

产品编号

说明

价格

Astec^® CHIROBIOTIC^® V 手性 HPLC 色谱柱

5 μm particle size, L × I.D. 25 cm × 4.6 mm

标准

产品编号

说明

价格

Sibutramine 盐酸盐一水合物

≥98% (HPLC), solid

CONDITIONS

column

CHIROBIOTIC V, 25 cm x 4.6 mm I.D., 5 μm particles (11024AST)

mobile phase

15 mM ammonium formate in methanol

flow rate

1 mL/min

column temp.

25 °C

detector

UV, 230 nm

injection

5 μL

sample

1 mg/mL in methanol

说明

分析说明

Sibutramine, one of a few drugs approved for long-term treatment of obesity, is a chiral compound. The (R) enantiomer has the desired effect of reducing body weight and food intake, but the (S) enantiomer has the opposite effect: A perfect example of why chiral HPLC is important to pharmaceutical and clinical analysts. Astec^® CHIROBIOTIC^® V successfully separates sibutramine enantiomers, using a simple, MS-friendly mobile phase.

法律信息

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

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Related Applications

Small Molecule HPLC Large Molecule HPLC Gas Chromatography (GC)TLC Solid Phase Microextraction (SPME)Solid Phase Extraction (SPE)QuEChERS

HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V

材料