- Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation
Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation
EMBO reports (2017-05-17)
Wei-Hung Jung, Chung-Chih Liu, Yu-Lian Yu, Yu-Chin Chang, Wen-Yu Lien, Hsi-Chun Chao, Shu-Yi Huang, Ching-Hua Kuo, Han-Chen Ho, Chih-Chiang Chan
PMID28507162
摘要
Dihydroceramide desaturases are evolutionarily conserved enzymes that convert dihydroceramide (dhCer) to ceramide (Cer). While elevated Cer levels cause neurodegenerative diseases, the neuronal activity of its direct precursor, dhCer, remains unclear. We show that knockout of the fly dhCer desaturase gene,