推荐产品
生物来源
synthetic (organic)
质量水平
检测方案
≥99% (HPLC)
形式
powder
mp
~300 °C (dec.) (lit.)
溶解性
DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow
SMILES字符串
Cn1cnc(N)c2ncnc12
InChI
1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
InChI key
FSASIHFSFGAIJM-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
应用
3-甲基腺嘌呤作为自噬抑制剂已用于：
- 使用转染人骨髓间充质干细胞(BM-MSC)检测自噬相关基因（Beclin 1，轻链3(LC3)和p62）的表达
- 协同顺铂(cisplatin)研究A2780cp细胞的自噬抑制会否影响顺铂诱导的细胞凋亡
- 研究多黏菌素(colistin)诱导的自噬和凋亡之间的相互作用
3-甲基腺嘌呤（3-MA）用于抑制和研究多种条件下自噬（溶酶体自我降解）和细胞凋亡的机制。3-MA可通过抑制III型磷脂酰肌醇3-激酶（PI-3K）阻断自噬体的形成来对自噬进行抑制。 3-MA通常以5 mM的浓度用作自噬抑制剂。
在癌症生成过程中核酸甲基化检测的标准品。
生化/生理作用
3-甲基腺嘌呤（3-MA）用于抑制和研究多种条件下自噬（溶酶体自我降解）和细胞凋亡的机制。3-MA可通过抑制III型磷脂酰肌醇3-激酶（PI-3K）阻断自噬体的形成来对自噬进行抑制。
制备说明
该产品可溶于DMF（10 mg/mL；可能需要温和受热）。 受热情况下，其可以30 mg/ml的浓度溶于水、95％乙醇或1 N NaOH，但在冷却后会从溶液中析出。 可在DMSO中配制100 mM的3-MA溶液。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jingyuan Chen et al.
Shock (Augusta, Ga.), 52(1), 111-121 (2018-10-05)
Sepsis-induced myopathy is a heavy burden for patients during respiratory failure as well as after discharge, which could be characterized with qualitative changes to nAChR in a rat model of sepsis, regulated by NRG-1. Autophagy is an innate immune defense
Heng Wang et al.
Journal of dairy science, 102(9), 8264-8272 (2019-07-01)
Staphylococcus aureus is an important pathogen causing chronic and subclinical mastitis of cows. Autophagy is an important regulatory mechanism that participates in the elimination of invading pathogenic organisms. Here, we hypothesize that autophagy is involved in the process of Staph.
Ruishuang Ma et al.
Cancer biology & therapy, 20(9), 1206-1212 (2019-05-17)
Autophagy plays a complicated role in tumorigenesis, and the effects of autophagy in drug resistance have not been fully known. The aim of this study was to evaluate autophagy activity in lung cancer cells derived from different origins and explore
Xiao Ye et al.
Peptides, 119, 170120-170120 (2019-07-28)
Insulin resistance (IR) is a fundamental pathogenic factor shared by a myriad of metabolic disorders, including obesity and type 2 diabetes. The mechanism of IR is usually accompanied by mitochondrial dysfunction. Irisin has been proposed to act as a hormone
Shuyan Wang et al.
Cell transplantation, 28(6), 775-782 (2019-01-23)
Astrocytes protection and functional regulation are important strategies to protect against neuronal damage caused by ischemia. Activation of the delta opioid receptor (DOR) could reduce astrocytes damage, although the mechanism remains unclear. The present study aimed to test the effect
商品
We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance
High titer lentiviral particles for LC3 variants used for live cell analysis of cellular autophagy.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门