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Merck
CN

H7779

维甲酸对羟基苯胺

≥95%

别名:

4-HPR, N-(4-羟基苯基)视黄酰胺, 维甲酰酚胺

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关于此项目

经验公式(希尔记法):
C26H33NO2
化学文摘社编号:
分子量:
391.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
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InChI

1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+

SMILES string

CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1

InChI key

AKJHMTWEGVYYSE-FXILSDISSA-N

biological source

synthetic (organic)

assay

≥95%

form

powder

color

yellow to yellow-orange

storage temp.

−20°C

Quality Level

General description

视黄酸羟基苯胺是视黄酸的一种合成类似物。

Application

视黄酸羟基苯胺已被用于:
  • 作为合成型视黄酸用于诱导SEB-1皮脂细胞凋亡
  • 作为C2C12成肌细胞的培养基补剂以检测其对神经酰胺形成的影响
  • T细胞急性淋巴细胞白血病(T-ALL)中的细胞毒性检测

Biochem/physiol Actions

维生素 A 酸类似物具有抗增殖活性;诱导恶性造血细胞系凋亡。
视黄酸对羟基苯胺又称芬维A胺,可增加活性氧、激活半胱天冬酶并诱导细胞凋亡。它还可抑制二氢神经酰胺去饱和酶,从而引起神经酰胺生物合成的减少。芬维A胺可能对培养中的人乳腺癌细胞有抗肿瘤活性。它可作为胰岛素拮抗剂,并有助于治疗胰岛素抵抗。芬维A胺或4-HPR具有用于化疗的潜力,并对视黄酸具有耐受的癌细胞具有细胞毒性。

pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. In what solvents can product H7779, Retinoic acid p-hydroxyanilide, be dissolved?

    Product H7779, Retinoic acid p-hydroxyanilide, can be dissolved in DMSO (25 mg/ml) and ethanol (25 mg/ml).

  6. How can one store a solution of product H7779, Retinoic acid p-hydroxyanilide?

    A solution of product H7779, Retinoic acid p-hydroxyanilide, can be aliquoted and stored at -20°C for up to 3 months. Solutions should be protect from light.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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