跳转至内容
Merck
CN
  • Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2014-12-11)
Mario Ost, Susanne Keipert, Evert M van Schothorst, Verena Donner, Inge van der Stelt, Anna P Kipp, Klaus-Jürgen Petzke, Mariona Jove, Reinald Pamplona, Manuel Portero-Otin, Jaap Keijer, Susanne Klaus
摘要

Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory uncoupling in uncoupling protein 1 transgenic (UCP1-TG) mice as model of muscle-specific compromised mitochondrial function. Here we describe a detailed metabolic reprogramming profile associated with mitochondrial perturbations in SM, triggering an increased protein turnover and amino acid metabolism with induced biosynthetic serine/1-carbon/glycine pathway and the longevity-promoting polyamine spermidine as well as the trans-sulfuration pathway. This is related to an induction of NADPH-generating pathways and glutathione metabolism as an adaptive mitohormetic response and defense against increased oxidative stress. Strikingly, consistent muscle retrograde signaling profiles were observed in acute stress states such as muscle cell starvation and lipid overload, muscle regeneration, and heart muscle inflammation, but not in response to exercise. We provide conclusive evidence for a key compensatory stress-signaling network that preserves cellular function, oxidative stress tolerance, and survival during conditions of increased SM mitochondrial distress, a metabolic reprogramming profile so far only demonstrated for cancer cells and heart muscle.

材料
货号
品牌
产品描述

Sigma-Aldrich
L -还原型谷胱甘肽, suitable for cell culture, BioReagent, ≥98.0%, powder
登录查看公司和协议定价
货号包装规格是否有货价格数量
5 g
有货
详情...
CN¥1,199.60
10 g
有货
详情...
CN¥2,184.36
CN¥1,419.83
25 g
有货
详情...
CN¥3,622.34
100 g
有货
详情...
CN¥10,939.84
Sigma-Aldrich
L-苏氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 g
有货
详情...
CN¥1,088.56
100 g
有货
详情...
CN¥3,440.32
1 kg
有货
详情...
CN¥21,315.39
Sigma-Aldrich
抗-α微管蛋白抗体,小鼠单克隆抗体, clone B-5-1-2, purified from hybridoma cell culture
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 μL
有货
详情...
CN¥6,922.02
200 μL
有货
详情...
CN¥8,005.28
SAFC
L-苏氨酸
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 g
请联系客服了解存货情况
CN¥6,999.22
1 kg
请联系客服了解存货情况
CN¥27,159.55
10 kg
请联系客服了解存货情况
CN¥149,586.01
25 kg
请联系客服了解存货情况
CN¥320,298.50
Sigma-Aldrich
DL-甲硫氨酸, ≥99%
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 g
有货
详情...
CN¥666.24
500 g
有货
详情...
CN¥1,130.42
1 kg
有货
详情...
CN¥1,303.33
Sigma-Aldrich
L -还原型谷胱甘肽, ≥98.0%
登录查看公司和协议定价
货号包装规格是否有货价格数量
10 mg
预计发货时间 March 27, 2025
详情...
CN¥143.93
300 mg
有货
详情...
CN¥164.49
1 g
有货
详情...
CN¥384.10
CN¥249.66
5 g
有货
详情...
CN¥737.26
10 g
有货
详情...
CN¥1,159.54
CN¥753.70
25 g
有货
详情...
CN¥2,038.70
50 g
有货
详情...
CN¥3,786.19
100 g
有货
详情...
CN¥5,497.26
250 g
有货
详情...
CN¥10,193.53
500 g
有货
详情...
CN¥14,844.00
Sigma-Aldrich
L-苏氨酸, BioXtra, ≥99.5% (NT)
登录查看公司和协议定价
货号包装规格是否有货价格数量
10 g
有货
详情...
CN¥1,039.42
50 g
有货
详情...
CN¥2,483.25
250 g
预计发货时间 April 14, 2025
详情...
CN¥7,221.41
Sigma-Aldrich
DL-胱硫醚, ≥90% (HPLC)
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 mg
预计发货时间 May 20, 2025
详情...
CN¥2,010.54
500 mg
预计发货时间 May 20, 2025
详情...
CN¥8,937.51
Sigma-Aldrich
DL-甲硫氨酸, 99%, FCC, FG
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
L-苏氨酸, reagent grade, ≥98% (HPLC)
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
DL-亮氨酸, ≥99% (HPLC)
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
DL-甲硫氨酸, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
L -还原型谷胱甘肽, BioXtra, ≥98.0%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
L -还原型谷胱甘肽, Vetec, reagent grade, ≥98%
货号
包装规格
是否有货
价格
数量