One-pot transition-metal-free synthesis of dibenzo[b,f]oxepins from 2-halobenzaldehydes.

One-pot transition-metal-free synthesis of dibenzo[b,f]oxepins from 2-halobenzaldehydes.

Organic letters (2012-09-19)

Young Lok Choi, Hye Sun Lim, Hwan Jung Lim, Jung-Nyoung Heo

摘要

A one-pot transition-metal-free, base-mediated synthesis of dibenzo[b,f]oxepins was developed. The reaction of 2-halobenzaldehydes with (2-hydroxyphenyl)acetonitriles proceeds via a sequential aldol condensation and intramolecular ether formation reaction in the presence of Cs(2)CO(3) and molecular sieves in toluene.

材料

货号

品牌

产品描述

418099

Sigma-Aldrich

苯甲醛, purified by redistillation, ≥99.5%

B1334

Sigma-Aldrich

苯甲醛, ReagentPlus^®, ≥99%

PHR1203

Supelco