DBU-promoted cyclization of ortho-(3-hydroxy-1-alkynyl)benzamide: synthesis of trans-3,4-dihydroisoquinolin-1(2H)-ones and (E)-4-(1-alkenyl)isoquinolin-1(2H)-ones.

DBU-promoted cyclization of ortho-(3-hydroxy-1-alkynyl)benzamide: synthesis of trans-3,4-dihydroisoquinolin-1(2H)-ones and (E)-4-(1-alkenyl)isoquinolin-1(2H)-ones.

The Journal of organic chemistry (2012-01-19)

Wanli Chen, Jing Cui, Yinghong Zhu, Xianchao Hu, Weimin Mo

摘要

DBU-promoted cyclization of ortho-(3-hydroxy-1-alkynyl)benzamide is presented, providing an efficient method for the synthesis of trans-3,4-dihydroisoquinolin-1(2H)-ones and (E)-4-(1-alkenyl)isoquinolin-1(2H)-ones under mild conditions.

材料

货号

品牌

产品描述

139009

Sigma-Aldrich

1,8-二氮杂双环[5.4.0]十一碳-7-烯, 98%

33482

Sigma-Aldrich

1,8-二氮杂双环[5.4.0]十一碳-7-烯, puriss., ≥99.0% (GC)