跳转至内容
Merck
CN
  • The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast.

The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast.

Oncotarget (2018-12-18)
Nisha Durand, Sahra Borges, Tavia Hall, Ligia Bastea, Heike Döppler, Brandy H Edenfield, E Aubrey Thompson, Xochiquetzal Geiger, Peter Storz
摘要

Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through site-specific formation of phosphatidylinositol-4,5-bisphosphate (PI4,5P2). By comparing normal breast tissue to carcinoma in situ and invasive ductal carcinoma subtypes, we here show that the phosphorylation status of PIP5K1C at serine residue 448 (S448) can be predictive for breast cancer progression to an aggressive phenotype, while PIP5K1C expression levels are not indicative for this event. PIP5K1C phosphorylation at S448 is downregulated in invasive ductal carcinoma, and similarly, the expression levels of PKD1, the kinase that phosphorylates PIP5K1C at this site, are decreased. Overall, since PKD1 is a negative regulator of cell migration and invasion in breast cancer, the phosphorylation status of this residue may serve as an indicator of aggressiveness of breast tumors.

材料
货号
品牌
产品描述

Sigma-Aldrich
单克隆抗-FLAG® M2 小鼠抗, clone M2, purified immunoglobulin (Purified IgG1 subclass), buffered aqueous solution (10 mM sodium phosphate, 150 mM NaCl, pH 7.4, containing 0.02% sodium azide)
登录查看公司和协议定价
货号包装规格是否有货价格数量
10 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥1,028.09
CN¥705.96
50 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥3,390.80
Sigma-Aldrich
单克隆抗 β-肌动蛋白抗体 小鼠抗, clone AC-15, ascites fluid
登录查看公司和协议定价
货号包装规格是否有货价格数量
10 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥1,028.09
CN¥705.96
50 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥3,390.80
Sigma-Aldrich
Anti-PKD2 Antibody, Upstate®, from rabbit
登录查看公司和协议定价
货号包装规格是否有货价格数量
10 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥1,028.09
CN¥705.96
50 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥3,390.80
Sigma-Aldrich
Anti-PIP5K-Type 1 gamma Antibody, from rabbit
登录查看公司和协议定价
货号包装规格是否有货价格数量
10 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥1,028.09
CN¥705.96
50 mg
国内现货,预计发货时间 April 03, 2025
详情...
CN¥3,390.80