Parteck®功能型辅料-默克生命科学
在设计固体剂型时，需要考虑到许多因素：活性药物成分（API）、生物可用性增强、释放动力学、特定剂量、包装、保质期等。辅料是制剂的基础，影响最终制剂的属性，如可加工性、稳定性和性能等。因此，具有正确功能性和高品质的辅料至关重要。
我们的Parteck®功能型辅料在设计时就考虑到了这些挑战，并具有超出标准的额外功能性。这些辅料是颗粒优化的，具有适合压片工艺、用于特异性药物递送技术或增溶功能的独特颗粒属性。因此，我们的Parteck®功能型辅料可确保在制剂开发和制造中具有出色的性能。Parteck®赋形剂以严苛质控的Emprove®计划及监管支持和记录文档为依托，可帮助您加快审批进程。
灵活的压片
- 在低压力下具有高片剂硬度，兼具坚固性和快速崩解能力
- 独特的颗粒表面，支持高低API剂量
- 可直接压片、湿法和干法制粒、薄膜包衣、润滑和快速崩解的专业赋形剂
优化的药物递送
- 提供改良释放动力学选项，如口服崩解片和缓释固体口服制剂
- 适用于包括干粉吸入等不同给药途径的专门辅料
增强溶解性
- 用于热熔挤出、提高压片溶出度的专用辅料和具有独特表面结构的二氧化硅药物载体
- 提高的药物活性成分溶解度增进最终产品的功效
相关产品资源
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- Article: API Solubility and Dissolution Enhancement Via Formulation
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- Article: Improving API Solubility Using Hot Melt Extrusion Formulation With Polyvinyl Alcohol
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- Download: Formulation Handbook
Formulating pharmaceutical dosage forms: In this formulation handbook, we have compiled information and formulation examples that can help you when developing your formulation.
- White Paper: API Stability in Solid Dose Formulation – Exploring the Myth of Inert Excipients
Stable active pharmaceutical ingredients (APIs) are critical for drug formulation due to their impact on patient safety, regulatory acceptance, drug shelf-life, wastage, and storage requirements. API instability can lead to reduced drug dosage, formation of toxic degradation products, and increased costs for storage, potentially harming patient safety and economic viability.
- White Paper: New Opportunities for Oral Sustained Release Formulations with Polyvinyl Alcohol
Achieving appropriate release kinetics for an active pharmaceutical ingredient (API) is crucial for therapeutic success. Consistent API dosing in sustained release formulations ensures that blood plasma levels remain within the therapeutic window, maintaining efficacy while avoiding toxic side effects.
- White Paper: Considerations for Dosing Accuracy in a New Carrier for Dry Powder Inhalation
Inhalation drug delivery offers rapid action and good bioavailability, but precise dosing is difficult due to small dosage amounts and diverse forms of APIs.
- White Paper: The Developability Classification System (DCS): Enabling an Optimized Approach for Formulation of Poorly Soluble Molecules
Adequate solubility in gastrointestinal fluids is essential for the effectiveness of orally administered solid dosage forms. Most absorption occurs in the small intestine, where the drug needs to dissolve sufficiently to enter the systemic circulation. If the drug is not soluble in these fluids, it cannot produce the intended physiological effect.
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