聚合物_纳米粒子_生物医学材料_材料科学-默克生命科学
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Degradex® 聚合物微球和纳米粒子
我们提供基于 Degradex® PLGA 和 PCL 的普通和荧光微球和纳米粒子。普通 PLGA 微球和纳米粒子可作为控制剂用于药物和RNA递送制剂,或用于API载入载体前的系统相容性测试。荧光纳米粒子和微球可用于广泛的成像和诊断应用,如:
- 检测结合活动或型号增强
- 流体示踪
- 细胞追踪
- 吞噬研究
- 荧光显微镜
- 药物发现研究
- 药物载体(API可附着在粒子表面递送)
普通和荧光粒子通过羧基基团进行表面官能化,从而允许 蛋白、肽 、抗体、抗原以及小分子共价附着。
Degradex® 聚乳酸-羟基乙酸共聚物 (PLGA) 和聚己内酯微球和纳米粒子是具有可生物降解性和生物相容性的聚合物颗粒,直径范围 100 nm 到 50 μm。Degradex® 颗粒可用于在制药开发前证实药物载体的相容性。此外,颗粒通过羧基基团进行表面官能化,使 Degradex® 颗粒可以用于靶向治疗,增加循环时间。
我们的荧光聚乳酸-羟基乙酸共聚物 (PLGA) 颗粒的激发和发射波长为 460/500、 530/582、 644/665 和 780/820 nm,便于在各类生物成像和诊断应用中对颗粒进行可视化,包括细胞跟踪、吞噬研究、荧光显微镜和药物发现等应用。我们提供绿色、橙色、红色和近红外荧光 PLGA 颗粒,直径 100 nm 到 50 μm 规格可选。
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