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Merck
CN

1445200

USP

米托蒽醌 二盐酸盐

United States Pharmacopeia (USP) Reference Standard

别名:

1,4-二羟基-5,8-双-[[2-[(2-羟乙基)氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐

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关于此项目

经验公式(希尔记法):
C22H28N4O6 · 2HCl
化学文摘社编号:
分子量:
517.40
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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产品名称

米托蒽醌 二盐酸盐, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

SMILES string

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

InChI key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

mitoxantrone

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... TOP2A(7153)

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Biochem/physiol Actions

米托蒽醌是一种细胞抑制性蒽二酮,可嵌入 DNA 中,通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物,增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性,抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Mitoxantrone hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Mitoxantrone Injection

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Muta. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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