TOP2A
topoisomerase (DNA) II alpha 170kDa
别名:
TOP2, TP2A
物种:
Human TOP2A (7153), Mouse Top2a (21973), Rat Top2a (360243), dog TOP2A (480525), Domestic Rabbit TOP2A (100357676), Zebrafish top2a (323733), chicken TOP2A (395570), sheep TOP2A (101108762), domestic guinea pig Top2a (100730168), cow TOP2A (787696)
UniProtKB ID:
基因ID:
- Human(7153) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
- Mouse(21973) topoisomerase (DNA) II alpha
- Rat(360243) topoisomerase (DNA) II alpha
- dog(480525) topoisomerase (DNA) II alpha 170kDa
- Domestic Rabbit(100357676) topoisomerase (DNA) II alpha 170kDa
- Zebrafish(323733) topoisomerase (DNA) II alpha
- chicken(395570) topoisomerase (DNA) II alpha 170kDa
- sheep(101108762) topoisomerase (DNA) II alpha 170kDa
- domestic guinea pig(100730168) topoisomerase (DNA) II alpha 170kDa
- cow(787696) topoisomerase (DNA) II alpha 170kDa
- domestic cat(101083813) topoisomerase (DNA) II alpha 170kDa
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-Topoisomerase II Antibody, clone 3C3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse
应用
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
TOP2A (Topoisomerase IIα) Rabbit Monoclonal Antibody, clone RM394, affinity purified immunoglobulin,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
物种反应性
human
应用
immunohistochemistry
Anti-Topoisomerase II Antibody, clone KiS1, clone KiS1, Chemicon®, from mouse,
物种反应性
human
应用
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
货号
说明
物种