跳转至内容

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

For important updates on recent policy changes, please click here for more details.

Merck
CN
所有图片(3)

主要文件

查看所有文档

M6545

Sigma-Aldrich

米托蒽醌 二盐酸盐

≥97% (HPLC)

别名:

1,4-二羟基-5,8-双-[[2-[（2-羟乙基）氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐

登录查看公司和协议定价

选择尺寸

10 G
¥9,322.21

¥9,322.21

国内现货，预计发货时间2025年4月17日详情

获取大包装报价
所有图片(3)

选择尺寸

变更视图
10 G
¥9,322.21

About This Item

经验公式（希尔记法）:
C22H28N4O6 · 2HCl
CAS号:
70476-82-3
分子量:
517.40
EC 号:
274-619-1
MDL编号:
MFCD00242943
UNSPSC代码:
12352005
PubChem化学物质编号:
24278562
NACRES:
NA.25

¥9,322.21

国内现货，预计发货时间2025年4月17日详情

获取大包装报价

方案

≥97% (HPLC)

SMILES字符串

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChI key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

基因信息

human ... TOP2A(7153)

正在寻找类似产品? 访问 产品对比指南

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
101891019910197
Supelco

10184

Carbosieve Adsorbent

Carbosieve Adsorbent matrix Carbosieve S-II, 60-80 mesh, bottle of 10 g

10189

Carbosieve Adsorbent

Supelco

10199

Carbosieve Adsorbent

Supelco

10197

Carbosieve Adsorbent

particle size

60-80 mesh

particle size

60-80 mesh

particle size

80-100 mesh

particle size

45-60 mesh

pore size

~0.04 cm3/g mesoporosity, ~0 cm3/g macroporosity, ~0.35 cm3/g microporosity, ~4-11 pore diameter

pore size

~0.01 cm3/g mesoporosity, ~0.45 cm3/g microporosity, ~0 cm3/g macroporosity, ~6-15 Å pore diameter

pore size

~0.02 cm3/g mesoporosity, ~0.49 cm3/g microporosity, ~0 cm3/g macroporosity, ~6-15 Å pore diameter

pore size

~0.02 cm3/g mesoporosity, ~0.49 cm3/g microporosity, ~0 cm3/g macroporosity, ~6-15 Å pore diameter

surface area

~975 m2/g

surface area

~1059 m2/g

surface area

~1160 m2/g

surface area

~1160 m2/g

packaging

bottle of 10 g

packaging

bottle of 10 g

packaging

bottle of 5 g

packaging

bottle of 5 g

matrix

Carbosieve™ S-III

matrix

Carbosieve™ S-II

matrix

Carbosieve™ G

matrix

Carbosieve™ G

应用

盐酸米托蒽醌已用于：
  • 诱导细胞表达钙网蛋白[1][2]
  • 作为遗传毒素剂[3]
  • 作为拓扑异构酶抑制剂[4]

生化/生理作用

米托蒽醌是一种细胞抑制性蒽二酮，可嵌入 DNA 中，通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物，增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性，抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H340,H360

危险分类

Muta. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    MKCX5450
    MKCT3297
    MKCQ3047
    MKCM8540
    MKCL5878

    没有发现合适的版本？

    如果您需要特殊版本，可通过批号或批次号查找具体证书。

    搜索COA

    已有该产品？

    在文件库中查找您最近购买产品的文档。

    访问文档库

    A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
    FitzGerald J
    PLoS ONE, 9, e98891-e98891 (2014)
    Vugar Yagublu et al.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 13(1), 79-87 (2013-02-12)
    Peritoneal carcinomatosis is a common cause of death in pancreatic cancer patients. In this metastatic stage of the disease, few patients show a sustained response to therapy. In the palliative situation, targeted and compartment restricted delivery of drugs offers the
    James M Stankiewicz et al.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 10(1), 77-88 (2012-12-29)
    Immunosuppressives have been used in multiple sclerosis (MS) since 1966. Today, we have many treatments for the relapsing forms of the disease, including 8 US Food and Drug Administration-approved therapies, with more soon to be introduced. Given the current treatment
    Chyuan-Chuan Wu et al.
    Nucleic acids research, 41(22), 10630-10640 (2013-09-17)
    Type II topoisomerases (Top2s) alter DNA topology via the formation of an enzyme-DNA adduct termed cleavage complex, which harbors a transient double-strand break in one DNA to allow the passage of another. Agents targeting human Top2s are clinically active anticancer
    Yuting Ma et al.
    The Journal of experimental medicine, 208(3), 491-503 (2011-03-09)
    By triggering immunogenic cell death, some anticancer compounds, including anthracyclines and oxaliplatin, elicit tumor-specific, interferon-γ-producing CD8(+) αβ T lymphocytes (Tc1 CTLs) that are pivotal for an optimal therapeutic outcome. Here, we demonstrate that chemotherapy induces a rapid and prominent invasion
    查看所有相关文献

    商品

    DNA Damage and Repair

    DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

    DNA损伤和修复

    DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

    我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

    联系客户支持