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M6545

Sigma-Aldrich

米托蒽醌 二盐酸盐

≥97% (HPLC)

别名:

1,4-二羟基-5,8-双-[[2-[（2-羟乙基）氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐

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About This Item

经验公式（希尔记法）:
C22H28N4O6 · 2HCl
CAS号:
70476-82-3
分子量:
517.40
EC 号:
274-619-1
MDL编号:
MFCD00242943
UNSPSC代码:
12352005
PubChem化学物质编号:
24278562
NACRES:
NA.25

质量水平

100

方案

≥97% (HPLC)

SMILES字符串

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChI key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

基因信息

human ... TOP2A(7153)

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应用

盐酸米托蒽醌已用于：
  • 诱导细胞表达钙网蛋白
  • 作为遗传毒素剂
  • 作为拓扑异构酶抑制剂

生化/生理作用

米托蒽醌是一种细胞抑制性蒽二酮，可嵌入 DNA 中，通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物，增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性，抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H340,H360

危险分类

Muta. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
MKCT3297
MKCQ3047
MKCM8540
MKCL5878
MKCG7209

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