所有图片(1)
别名:
道诺霉素 盐酸盐
经验公式（希尔记法）:
C27H29NO10 · HCl
CAS号:
分子量:
563.98
Beilstein:
4229221
EC 号:
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
生物来源
synthetic
质量水平
检测方案
≥90% (HPLC)
形式
powder
颜色
red to deep red
抗生素抗菌谱
neoplastics
作用机制
DNA synthesis | interferes
储存温度
2-8°C
SMILES字符串
Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
InChI
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
基因信息
human ... TOP2A(7153)
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相关类别
一般描述
Chemical structure: aminoglycoside
应用
Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies.
生化/生理作用
On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
强效抗癌药。抑制 DNA 和 RNA 合成，作为序列特异性 ds-DNA 嵌入剂。
包装
5 mg, 25 mg
其他说明
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
Jay Chhablani et al.
Investigative ophthalmology & visual science, 54(2), 1268-1279 (2013-01-17)
To test the feasibility of covalent loading of daunorubicin into oxidized porous silicon (OPS) and to evaluate the ocular properties of sustained delivery of daunorubicin in this system. Porous silicon was heat oxidized and chemically functionalized so that the functional
Cedric Dos Santos et al.
Blood, 122(11), 1900-1913 (2013-07-31)
The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with
Sarah Bertoli et al.
Blood, 121(14), 2618-2626 (2013-02-01)
In acute myeloid leukemia (AML), new strategies assess the potential benefit of genetically targeted therapy at diagnosis. This implies waiting for laboratory tests and therefore a delay in initiation of chemotherapy. We studied the impact of time from diagnosis to
Oliver Teuffel et al.
British journal of haematology, 161(2), 192-203 (2013-02-13)
This systematic review and meta-analysis compared the efficacy of different anthracyclines and anthracycline dosing schedules for induction therapy in acute myeloid leukaemia in children and adults younger than 60 years of age. Twenty-nine randomized controlled trials were eligible for inclusion in
Kevin W H Yee et al.
Blood, 104(13), 4202-4209 (2004-08-12)
Fetal liver tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutations are the most common molecular abnormality associated with adult acute myeloid leukemia (AML). To exploit this molecular target, a number of potent and specific FLT3 kinase inhibitors have been
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