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预计发货时间2025年5月16日详情
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一般描述
拓扑异构酶 Ⅱα由位于人类染色体 17q21.2 上的 TOP2A 基因编码。通过在复制、重组和转录过程中可逆地断裂 DNA 链，对控制 DNA 的拓扑状态至关重要。TOP2A 在细胞周期的 S 期晚期和 G2/M 期表达增加，有丝分裂后表达减少。[1]TOP2A 的多态性引起染色体不稳定和肿瘤发生。[2]TOP2A 在乳腺癌、卵巢癌和前列腺癌等多种癌症类型中引起肿瘤增殖和侵袭性。[3]
拓扑异构酶 Ⅱα（拓扑 iiα）是一种具有保守催化活性的基因产物，它促进 DNA 损伤的进程。α异构体存在于增殖细胞中。 [4]
生化/生理作用
用于研究 DNA 结构和拓扑结构。
单位定义
一个单元将在37℃ 下 30 min内衰减 0.2μg 的动基体 DNA。
外形
缓冲甘油水溶液，含有三羟甲基氨基甲烷缓冲液 (pH 7.7)。溶液中还存在其他成分，可从技术服务部获得这些成分的批次特定信息。
制备说明
在专有真核细胞系中过表达的重组酶。
法律信息
TOPO is a registered trademark of Life Technologies
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
J R Spitzner et al.
Nucleic acids research, 16(12), 5533-5556 (1988-06-24)
Topoisomerase II, purified from chicken erythrocytes, was reacted with a large number of different DNA fragments and cleavages were catalogued in the presence and absence of drugs that stabilize the cleavage intermediate. Cleavages were sequenced to derive a consensus for
TOP2A induces malignant character of pancreatic cancer through activating beta-catenin signaling pathway.
Pei YF, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 197-207 (2018)
Raj Kumar Mandraju et al.
Archives of biochemistry and biophysics, 470(1), 27-34 (2007-11-21)
Topoisomerase II alpha (TopoIIalpha) and Topoisomerase II beta (TopoIIbeta) isoforms are different gene products having conserved catalytic activities. The alpha isoform is present in proliferating cell, while beta isoform is predominantly present in non-proliferating cells namely neurons suggesting its role
Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?
Romero A, et al.
Clinical And Translational Oncology, 14(3), 163-168 (2012)
The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer.
An X, et al.
BMC Cancer, 18(1), 331-331 (2018)
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