等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to BP 990
traceable to Ph. Eur. D2975000
traceable to USP 1225703
API类
doxorubicin
形式
powder
CofA
current certificate can be downloaded
包装
pkg of 200 mg
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
216 °C (dec.) (lit.)
应用
pharmaceutical (small molecule)
储存温度
-10 to -25°C
SMILES字符串
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
基因信息
human ... TOP2A(7153)
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一般描述
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.
应用
This pharmaceutical secondary standard can also be used as follows:
- Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples
- Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe2O4) modified carbon paste electrode in biological fluid and injection samples
- Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
- RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations
- Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples
分析说明
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
附注
To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
推荐产品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
A simple HPLC bioanalytical method for the determination of doxorubicin hydrochloride in rat plasma: application to pharmacokinetic studies
Dharmalingam SR, et al.
Tropical Journal of Pharmaceutical Research, 13, 409-415 (2014)
Fast and sensitive determination of doxorubicin using multi-walled carbon nanotubes as a sensor and CoFe2O4 magnetic nanoparticles as a mediator
Taei M, et al.
Microchimica Acta, 183, 49-56 (2016)
Simultaneous determination of doxorubicin and dasatinib as two breast anticancer drugs uses an amplified sensor with ionic liquid and ZnO nanoparticle
Alavi-Tabari SAR, et al.
Journal of Electroanalytical Chemistry, 811, 84-88 (2018)
Development and validation of RP-HPLC method for determination of doxorubicin hydrochloride from vacuum foam dried formulation
Hajare AA, et al.
Research Journal of Pharmacy and Technology, 9, 1352-1356 (2016)
Yi-Fang Yang et al.
The Kaohsiung journal of medical sciences, 35(7), 408-416 (2019-04-20)
Breast cancer is the most common female-specific malignancy in Taiwan and developed countries worldwide, and its incidence continues to grow. 14-3-3ε (YWHAE), which belong to 14-3-3 family, it has been reported up-regulated in breast cancer tissues. However, the clinical implication
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