1205003
USP
(+)-顺式-地尔硫卓 盐酸盐
United States Pharmacopeia (USP) Reference Standard
别名:
(2S,3S)-(+)-顺式-3-乙酰氧基-5-(2-二甲基氨基乙基)-2,3-二氢-2-(4-甲氧基苯基)-1,5-苯并硫氮杂-4(5H)- 酮 盐酸盐, CRD-401
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About This Item
经验公式（希尔记法）:
C22H26N2O4S · HCl
CAS号:
分子量:
450.98
Beilstein:
4228706
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
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等级
pharmaceutical primary standard
API类
diltiazem
制造商/商品名称
USP
应用
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
InChI
1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
InChI key
HDRXZJPWHTXQRI-BHDTVMLSSA-N
基因信息
human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)
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相关类别
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
- Exploring the Effectiveness of Carboxymethylated and Crosslinked Albizia procera Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis. This study investigates the potential of carboxymethylated and crosslinked Albizia procera gum for use in sustained-release matrix tablets containing Diltiazem hydrochloride, highlighting its viability in pharmaceutical applications (Mukherjee S, Khanam J, 2024).
- Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions. While primarily focused on gallic acid, this review mentions Diltiazem hydrochloride in the context of drug interactions and its implications in food safety and health (Xiang Z et al., 2024).
- Dual stimuli-responsive and sustained drug delivery NanoSensoGel formulation for prevention of cisplatin-induced ototoxicity. This research presents a novel NanoSensoGel that could be adapted for Diltiazem hydrochloride, enhancing drug delivery efficiency in clinical settings (Thakur NS et al., 2024).
- A novel potentiometric sensor based on ZnO decorated polyaniline/coal nanocomposite for diltiazem determination. This study develops a new sensor for the precise measurement of Diltiazem levels in pharmaceutical formulations, which is crucial for quality control and regulatory compliance (El Sayed GA et al., 2023).
- The Effect of Topical Nifedipine versus Diltiazem on the Acute Anal Fissure: A Randomized Clinical Trial. This clinical trial evaluates the effectiveness of Diltiazem hydrochloride in treating acute anal fissures, providing evidence of its beneficial applications in proctological disorders (Momayez Sanat Z et al., 2023).
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他说明
Sales restrictions may apply.
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说明
价格
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Diltiazem hydrochloride.
B F McGraw
Drug intelligence & clinical pharmacy, 16(5), 366-370 (1982-05-01)
K Adibkia et al.
Drug research, 64(4), 203-207 (2013-09-13)
The aim of this study was to design and evaluate diltiazem hydrochloride controlled porosity osmotic pump (CPOP) system employing a new coating technique named the micro suspension coating method. In this method the fast dissolving pore formers were suspended in
[Diltiazem hydrochloride: synthetic and pharmacological studies and development].
K Abe et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(8), 716-732 (1988-08-01)
B J McAuley et al.
Pharmacotherapy, 2(3), 121-133 (1982-05-01)
Diltiazem, a calcium channel blocking agent, has potent cardiovascular effects that are directly related to its influence on vascular smooth muscle, ventricular myocardium, and specialized conducting tissue. It causes coronary and peripheral vasodilation, has a negative chronotropic and dromotropic effect
Takeshi Ogura et al.
Acta neurochirurgica. Supplement, 120, 47-50 (2014-11-05)
This study evaluated the effect of diltiazem, a calcium antagonist, on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage (SAH) during the hyperacute stage. Of patients with aneurysmal SAH who underwent aneurysm repair between August 2008 and June 2011, 119
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