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59680-U

Supelco

Supel™ BioSPME 96-Pin Device

pack of 1 ea

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别名:
Supel™ BioSPME 96-Pin Device
UNSPSC代码:
41104018
NACRES:
NB.21

包装

pack of 1 ea

质量水平

100

技术

solid phase microextraction (SPME): suitable

基质活性基团

C18 coating

应用

clinical
pharmaceutical

相容性

for use with automated robotic liquid handling systems

相关类别

一般描述

The Supel™ BioSPME 96-Pin Device combines BioSPME technology with high throughput free fraction determination for plasma protein binding studies and other free analyte analyses commonly performed by pharma and clinical laboratories. This fast, micro-sample prep device comprises a 96-pin universal format that fits into the wells of standard 96-well plates. The pins are coated with C18 particles and a patented binder that allows for small analytes of interest to bind, while larger macromolecules cannot. This extraction technique is shown to be more than three times faster than rapid equilibrium dialysis methods with improved data quality. Supel™ BioSPME 96-Pin Device workflow can be performed on automation robots via handling with standard gripper paddles, or alternatively can be achieved using a manual technique.

分析说明

small molecules having molecular weights up to 1 kDa and logP range from 1-5

法律信息

Supel is a trademark of Sigma-Aldrich Co. LLC

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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商品

BioSPME for Plasma Protein Binding Assay: Details of Method Development and Optimization

Determination of plasma protein binding using a SupelTM C18 pin device based BioSPME method for efficient sample preparation, along with a comparison to the equilibrium dialysis method.

Sample Cleanliness Using BioSPME

Learn about Supel™ BioSPME C18 96-pin tool to prepare a clean sample with minimal matrix effects for an LC-MS/MS analysis from human plasma and its comparison with acetonitrile-based precipitation.

Protein Binding Determination Using Supel™ BioSPME C18 Pin Device as Part of the Manual Methodology With and Without Shaking

The application note describes a comparative analysis of plasma protein binding results for free/bound drugs using two different sample extraction steps, with and without agitation.

Speed, Simplicity and Accuracy of Protein Binding Determination using BioSPME

Learn about Supel™ BioSPME C18 high-throughput devices to determine plasma protein binding and decrease the sample preparation time to less than an hour.

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相关内容

Supel™ BioSPME 96头固相微萃取装置

相对于快速平衡透析技术，Supel™ BioSPME 96头固相微萃取装置可提高血浆蛋白结合研究及其他游离分析物分析的速度和简便性，同时确保准确、可重现的LCMS结果。

Supel™ BioSPME 96-Pin Devices

Supel™ BioSPME 96-Pin devices enhance speed and simplicity for plasma protein binding studies and LCMS analyses.

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