product name
HybridSPE ®-PLus, volume 2 mL, pk of 20 ea
描述
96-well Plate
质量水平
产品线
HybridSPE®
组成
bed wt., 50 mg
包装
pk of 20 ea
技术
solid phase extraction (SPE): suitable
体积
2 mL
基质活性基团
zirconia-based phase
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一般描述
HybridSPE-PLus 是下一代 HybridSPE-Phospholipid 技术。其首创的 HybridSPE-Phospholipid 技术于 2008 年首次推出。它融合了传统蛋白沉淀的简单、标准化方法学与固相萃取 (SPE) 的专属性，用于在 LC-MS 分析前同时去除生物样品中的蛋白质和磷脂。与其他磷脂去除产品使用疏水保留机制去除生物样品中的磷脂质不同，HybridSPE-磷脂技术使用独特的 Lewis 酸/碱保留机制，使其能够将磷脂与即使是非常疏水的分析物（如维生素）分离，这些分析物通常与竞争性产品上的磷脂一起保留。
我们的 HybridSPE-PLus 产品提供了与传统 HybridSPE-磷脂产品相同的经过时间验证的化学性质，并根据多年的生产经验进行生产改进。这些生产改进使我们能够提高流动一致性，减少样品滞留体积，进一步提高分析物回收率和测定重现性。我们邀请客户体验我们最新技术——HybridSPE-PLus。
我们的 HybridSPE-PLus 产品提供了与传统 HybridSPE-磷脂产品相同的经过时间验证的化学性质，并根据多年的生产经验进行生产改进。这些生产改进使我们能够提高流动一致性，减少样品滞留体积，进一步提高分析物回收率和测定重现性。我们邀请客户体验我们最新技术——HybridSPE-PLus。
应用
- Development of a High-Throughput Analytical Method for Antimicrobials in Wastewater Using an Automated Pipetting and Solid-Phase Extraction System: This study highlights the utilization of HybridSPE®-PLus 96-Well Plates for environmental analyte testing in wastewater. The method incorporates high-throughput sample preparation and solid phase extraction to efficiently process large sample volumes, proving essential for monitoring pharmaceutical pollutants and ensuring environmental safety (Azuma et al., 2024).
- High-throughput DNA extraction and cost-effective miniaturized metagenome and amplicon library preparation of soil samples for DNA sequencing: This research utilizes HybridSPE®-PLus 96-Well Plates to streamline the preparation of soil sample libraries for high-throughput sequencing. The method emphasizes cost-efficiency and rapid processing, suitable for extensive environmental and biological studies, reflecting the plate′s versatility in sample preparation (Jensen et al., 2024).
- Solvent-free parallel artificial liquid membrane extraction for drugs of abuse in plasma samples using LC-MS/MS: The HybridSPE®-PLus 96-Well Plate is employed for innovative LC-MS/MS sample cleanup in the detection of drugs in plasma. This application underscores the plate′s capacity for enhancing analytical performance in forensic and clinical toxicology by providing a robust, reproducible method for drug testing (Fabris et al., 2024).
- High-throughput sequencing of insect specimens with sub-optimal DNA preservation using a practical, plate-based Illumina-compatible Tn5 transposase library preparation method: In this study, HybridSPE®-PLus 96-Well Plates facilitate high-throughput DNA extraction and sequencing of insect specimens. This highlights the plate′s crucial role in genomic research, particularly in the study of biodiversity and conservation biology, where rapid and efficient DNA analysis is required (Cobb et al., 2024).
- Simultaneous determination of twelve neonicotinoids and six metabolites in human urine with isotope-dilution UPLC-Q-Orbitrap HRMS: This publication details the use of HybridSPE®-PLus 96-Well Plates in a sophisticated chromatographic setup for the quantitative analysis of pesticides in biological samples. The method demonstrates the plates′ effectiveness in environmental and health-related studies, ensuring precise measurement and monitoring of hazardous substances (Zhang et al., 2024).
特点和优势
- 简单的 2-3 步标准方法学，类似于传统的蛋白沉淀，可同时去除蛋白质和磷脂
- 独特的 Lewis 酸/碱保留机制可有效去除亲水性和疏水性目标分析物的磷脂（与竞争性化学品不同），消除磷脂诱导的离子抑制
- 高重现性、一致的产品性能
- 为更长的色谱柱使用寿命和更短的仪器停机时间提供更清洁的样本
- 有 96 孔和 1 mL 吸附模块尺寸可供选择
法律信息
HybridSPE is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
商品
This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.
实验方案
Immunoassay-based methods for digitoxin or digoxin exist, but are time consuming, labor intensive, and not selective due to similarities in their chemical structures.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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