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Astec^® CHIROBIOTIC^® V2 Chiral (5 μm) HPLC Columns

Name: Astec<SUP>&#174;</SUP> CHIROBIOTIC<SUP>&#174;</SUP> V2 Chiral (5 μm) HPLC Columns
Brand: SUPELCO

L × I.D. 25 cm × 4.6 mm, HPLC Column

别名:

Chirobiotic V2 TM=["Astec"] Chromatography Column

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About This Item

UNSPSC代码:

41115700

eCl@ss:

32110501

NACRES:

SB.52

product name

Astec^® CHIROBIOTIC^® V2手性HPLC色谱柱, 5 μm particle size, L × I.D. 25 cm × 4.6 mm

物料

stainless steel column

质量水平

100

Agency

suitable for USP L88

描述

HPLC column

产品线

Astec^®

包装

pkg of 1 ea

制造商/商品名称

Astec^®

参数

0-45 °C temperature
241 bar pressure (3500 psi)

技术

HPLC: suitable
LC/MS: suitable

长度 × 内径

25 cm × 4.6 mm

基质

High-purity silica gel particle platform
fully porous particle

基质活性基团

vancomycin phase

粒径

5 μm

孔径

200 Å

operating pH range

3.5-7.0

分离技术

chiral

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一般描述

中性分子、酰胺、酸、酯和胺对这些基于万古霉素的CSP显示出相当大的对映选择性。在CHIROBIOTIC^® V的极性离子模式下，分离出各种各样的仲胺和叔胺分子。CHIROBIOTIC^® V已经表现出蛋白质固定相的许多分离特性，但同时具有出色的稳定性和更高的样品容量。一些尚未报道在任何其他手性固定相上得到分离的手性分析物被分离出来。CHIROBIOTIC^® V和V2的区别在于键合化学性质与载体颗粒的孔径不同，这赋予它们不同的选择性和制备能力。

键合相：万古霉素
工作pH范围：3.5 - 7.0
粒径：5、10或16 μm
孔径：100Å（CHIROBIOTIC^® V）或200Å（CHIROBIOTIC^® V2）

CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献

应用

Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry: This study utilized the CHIROBIOTIC^® V2 column to achieve chiral separation of dextromethorphan and levomethorphan in human hair, highlighting the column′s application in forensic toxicology for precise enantiomeric analysis (Ji et al., 2022).

Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma: This research demonstrates the application of CHIROBIOTIC^® V2 for pharmacokinetic studies in rats, establishing a method for enantioselective determination that can be crucial for drug development and therapeutic monitoring (Zhang et al., 2016).

New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase: The use of CHIROBIOTIC^® V2 column in developing a new HPLC method for the separation of warfarin enantiomers underscores its utility in clinical analysis and therapeutic drug monitoring, showing its broad applicability in biomedical research (Malakova et al., 2009).

法律信息

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

应用

产品编号

说明

价格

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分析证书(COA)

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Chromatography Liquid Chiral Separations

Xiao, T.L., et al.

Encyclopedia of Separation Science, 1-15 (2000)

Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity

Fuglseth, Erik, et al.

Tetrahedron, 65 (47), 9807-9813 (2009)

Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography?tandem mass spectrometry: Application to human ethanol interactions

Zhu, Hao-Jie, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (11-12), 783-788 (2011)

New chemo-enzymatic approaches for the synthesis of (R)- and (S)-bufuralol

Nagy, Botond, et al.

Tetrahedron Asymmetry, 25 (18-19), 1316-1322 (2014)

Development, optimization and validation of a sub-minute analytical enantioselective high performance liquid chromatographic separation for a folic acid precursor in normal phase mode.

Doris Frühauf et al.

Journal of chromatography. A, 1269, 242-254 (2012-10-30)

A sub-minute enantioselective normal phase high performance liquid chromatographic (HPLC) method for the analysis of a chiral precursor molecule employed frequently in folic acid syntheses was developed, optimized and successfully validated according to ICH-guidelines. It could be shown that ultra-high

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实验方案

Chiral LC-MS Analysis of Methamphetamine in Urine on Astec^® CHIROBIOTIC^® V2

Efficient LC-MS separation of methamphetamine enantiomers in urine allows sensitive differentiation of illicit D-methamphetamine from over-the-counter L-methamphetamine.

Accurate Biological Testing for Amphetamine and Methamphetamine Abuse Using Chiral HPLC and MS Detection

Optimized sample prep and chiral chromatography methods for the LC/MS analysis of these drug enantiomers in urine

Biological Testing for Amphetamine and Methamphetamine Abuse

In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine.

Chromatograms

HPLC Analysis of Dorzolamide Enantiomers on Astec^® CHIROBIOTIC^® V2

application for HPLC

HPLC Analysis of Amphetamine and Methamphetamine Enantiomers on Astec^® CHIROBIOTIC^® V2

application for HPLC

HPLC Analysis of Dextromethorphan Enantiomers on Astec^® CHIROBIOTIC^® V2

application for HPLC

HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec^® CHIROBIOTIC^® V2

application for HPLC展开

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Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 4.6 mm, HPLC Column

About This Item

属性

product name

物料

质量水平

Agency

描述

产品线

包装

制造商/商品名称

参数

技术

长度 × 内径

基质

基质活性基团

粒径

孔径

operating pH range

分离技术

相关类别

说明

一般描述

应用

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法律信息

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文件

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Astec^® CHIROBIOTIC^® V2 Chiral (5 μm) HPLC Columns