推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 120 kDa
种属反应性
human
浓度
~1 mg/mL
技术
indirect immunofluorescence: 5-10 μg/mL using MCF7 cells fixed with paraformaldehyde-Triton
western blot: 0.5-1 μg/mL using MCF-7 cell lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... XPC(7508)
一般描述
DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) is a DNA damage recognition factor. The protein consists of 940 amino acids. The gene encoding XPC is localized on human chromosome 3p25.1 and consists of 18 exons.
XPC exists in vivo as a heterotrimeric complex with one of the two mammalian homologs of S. cerevisiae Rad23 (HR23A or HR23B) and centrin 2.
免疫原
synthetic peptide corresponding to amino acids 922-940 of human XPC, conjugated to KLH via an N-terminal added cysteine residue.
应用
Anti-XPC (C-terminal) antibody produced in rabbit has been used in indirect immunofluorescence and western blotting
生化/生理作用
DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) has a role in global genome nucleotide excision repair pathway. As part of the XPC complex, this protein binds to DNA sites having many lesions. Single nucleotide polymorphisms in the XPC gene have been linked to various cancers.
Defective XPC gene causes photosensitivity syndrome called xeroderma pigmentosum (XP), which is characterized by a very high incidence of light-induced skin cancer.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies
Neumann AS, et al.
Molecular Carcinogenesis, 42(2), 65-92 (2005)
Lack of Associations between XPC Gene Polymorphisms and Neuroblastoma Susceptibility in a Chinese Population.
Zheng J
BioMed Research International (2016)
Justin D Mallet et al.
PloS one, 11(9), e0162212-e0162212 (2016-09-10)
Absorption of UV rays by DNA generates the formation of mutagenic cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP). These damages are the major cause of skin cancer because in turn, they can lead to signature UV mutations.
Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.
Kakumu E
Genes Cells (2017)
Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation.
Cellular and Molecular Biology (2016)
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