所有图片(1)

主要文件

COO原产地证书/COA分析证书

查看所有文档

V3765

VU0255035 hydrate

Name: VU0255035 hydrate
Brand: SIGMA

≥98% (HPLC)

别名:

CID24768606, ML012, N-(3-oxo-3-(4-(pyridine-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide hydrate, N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide hydrate

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₈H₂₀N₆O₃S₂ · xH₂O

CAS号:

1135243-19-4

分子量:

432.52 (anhydrous basis)

MDL编号:

MFCD16875440

UNSPSC代码:

12352200

PubChem化学物质编号:

329829045

NACRES:

NA.77

推荐产品

Slide 1 of 10

1 of 10

Sigma-Aldrich

5.05772

Pirenzepine Dihydrochloride

Sigma-Aldrich

M105

美索曲明水合物

Sigma-Aldrich

T9778

托吡卡胺

Sigma-Aldrich

V4640

VU0357017 monohydrochloride

Sigma-Aldrich

P7412

哌仑西平二盐酸盐

Sigma-Aldrich

SML0255

4-DAMP

Sigma-Aldrich

T103

三氟哌丁苯盐酸盐

Sigma-Aldrich

SML0035

Tiagabine hydrochloride

Sigma-Aldrich

SML2868

Aclidinium bromide

Supelco

Z-007

唑吡坦苯基-4-羧酸溶液

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

yellow

溶解性

DMSO: >5 mg/mL

储存温度

−20°C

SMILES字符串

O.O=C(CCNS(=O)(=O)c1cccc2nsnc12)N3CCN(CC3)c4ccncc4

InChI

1S/C18H20N6O3S2.H2O/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15;/h1-5,7-8,20H,6,9-13H2;1H2

InChI key

NURHGMDBQMBSQI-UHFFFAOYSA-N

生化/生理作用

VU0255035 is the first highly selective antagonist at the orthosteric site of the M1 receptor (75-fold selective for M1 relative to other muscarininc subtypes and devoid of activity at other GPCRs, ion channels, transporters and kinases).

VU0255035 is the first highly selective antagonist at the orthosteric site of the M1 receptor (75-fold selective for M1 relative to other muscarininc subtypes and devoid of activity at other GPCRs, ion channels, transporters and kinases). There are no highly selective M1 muscarinic receptor antagonists. The existing non-selective drugs do not permit direct evaluation of the role of M1 receptors in CNS fucntions and do not premit therapeutic targeting of M1 receptors in various disease states in which M1 receptors are implicated (epilepsy, Parkinson′s disease, attention and cognitive disorders, dystonia, etc).

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.