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About This Item
经验公式（希尔记法）:
C9H12N2Na3O15P3 · xH2O
CAS号:
分子量:
550.09 (anhydrous basis)
Beilstein:
3585234
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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类型
Type IV
质量水平
方案
≥93.0% (HPLC)
溶解性
H2O: soluble 25 mg of UTP in 0.5 ml of solvent, clear, colorless
储存温度
−20°C
SMILES字符串
[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O
InChI
1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
InChI key
MMJGIWFJVDOPJF-LLWADOMFSA-K
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应用
UTP 已被用作 P2 受体激活剂，研究其对 MC3T3-E1 和 UMR-106 细胞质子外流的影响 。还研究了 UTP 与盐酸阿米洛利雾化溶液联合治疗囊性纤维化 。
尿苷 5′-三磷酸盐曾用于一项研究显示氟西汀 (FLX) 通过增加腺苷 5′ 的胶质传递而介导其抗抑郁作用-三磷酸盐 (ATP)。
生化/生理作用
P2Y 受体激动剂。
尿苷-5′-三磷酸盐 (UTP) 是核酸的细胞溶质核苷酸成分。作为细胞外间隙中的信号分子。尿苷-5′-三磷酸盐 (UTP) 参与神经系统的多种病理生理反应。UTP 在再生过程中也起主要角色。
包装
无底玻璃瓶。内含物装在插入的融合锥内。
制备说明
25 mg 尿苷 5'-三磷酸三钠盐 (UTP Na 3 ) 水合物可溶于 0.5 mL 水中，并产生澄清、无色溶液。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Uridine-5?-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells
Palomo-Guerrero M, et al.
Neuroscience, 372(2), 255-265 (2018)
Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes
Kinoshita M, et al.
EBioMedicine, 372(2), 255-265 (2018)
Intralesional uridine-5?-triphosphate (UTP) treatment induced resistance to Leishmania amazonensis infection by boosting Th 1 immune responses and reactive oxygen species production
Marques-da-Silva C, et al.
Purinergic Signaling, 14(2), 201-211 (2018)
Ronald J Pettis et al.
Journal of pharmaceutical sciences, 93(9), 2399-2406 (2004-08-06)
Combination therapy using nebulized amiloride hydrochloride and uridine-5'-triphosphate (UTP) trisodium salt aerosols has been investigated for the treatment of cystic fibrosis (CF). Amiloride in aqueous solution precipitates in the presence of UTP, reducing drug concentrations. Interactions between these drugs and
Matthew W Grol et al.
American journal of physiology. Endocrinology and metabolism, 302(5), E561-E575 (2011-12-22)
The P2X₇ receptor is an ATP-gated cation channel expressed by a number of cell types, including osteoblasts. Genetically modified mice with loss of P2X₇ function exhibit altered bone formation. Moreover, activation of P2X₇ in vitro stimulates osteoblast differentiation and matrix
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