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Merck
CN

U6625

尿苷-5′-三磷酸酯 三钠盐 水合物

From yeast, ≥96%, P2Y receptor agonist

别名:

UTP Na3

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关于此项目

经验公式(希尔记法):
C9H12N2Na3O15P3 · xH2O
化学文摘社编号:
分子量:
550.09 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
3585234
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产品名称

尿苷-5′-三磷酸酯 三钠盐 水合物, from yeast, Type III, ≥96%

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

biological source

yeast

type

Type III

assay

≥96%

solubility

H2O: soluble 50 mg/mL, clear to slightly hazy, colorless

shipped in

dry ice

storage temp.

−20°C

Quality Level

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Application

UTP已用于研究其对糖尿病患者的骨骼肌细胞的血管舒张作用。UTP 还被用作嘌呤能激动剂来研究 P2Y2 受体在大鼠基底外侧膜上的离子转运功能

Biochem/physiol Actions

P2Y 受体激动剂。

Preparation Note

尿苷 5′-三磷酸三钠盐(UTP Na3)水合物,以 50mg/ml的浓度溶于水,产生澄清至轻微浑浊的无色溶液。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Satyanarayana R Pondugula et al.
BMC research notes, 3, 100-100 (2010-04-20)
The ionic composition of the luminal fluid in the vestibular labyrinth is maintained within tight limits by the many types of epithelial cells bounding the lumen. Regulatory mechanisms include systemic, paracrine and autocrine hormones along with their associated intracellular signal
Xiping Chen et al.
FEBS letters, 595(1), 110-122 (2020-10-25)
O-GlcNAcylation is a post-translational modification catalysed by O-GlcNAc transferase (OGT). Missense mutations in OGT have been associated with developmental disorders, OGT-linked congenital disorder of glycosylation (OGT-CDG), which are characterized by intellectual disability. OGT relies on the hexosamine biosynthetic pathway (HBP)
Alexander Puzenko et al.
The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)
In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy
Adelaine K W Leung et al.
Journal of molecular biology, 402(1), 154-164 (2010-07-21)
RNA is known to perform diverse roles in the cell, often as ribonucleoprotein (RNP) particles. While the crystal structure of these RNP particles could provide crucial insights into their functions, crystallographic work on RNP complexes is often hampered by difficulties
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Cell reports, 32(12), 108161-108161 (2020-09-24)
Sensing stressful conditions and adjusting the cellular metabolism to adapt to the environment are essential activities for bacteria to survive in variable situations. Here, we describe a stress-related protein, YdiU, and characterize YdiU as an enzyme that catalyzes the covalent

实验方案

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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