T8325
TDZD-8
≥98% (HPLC), needles
别名:
4-苄基-2-甲基-1,2,4-噻二唑烷-3,5-二酮
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H10N2O2S
化学文摘社编号:
分子量:
222.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
TDZD-8, ≥98% (HPLC), needles
InChI
1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
SMILES string
CN1SC(=O)N(Cc2ccccc2)C1=O
InChI key
JDSJDASOXWCHPN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
needles
storage condition
protect from light
color
white
mp
63-64.4 °C
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Application
TDZD-8已被用于研究GSK-3在维持MLL白血病干细胞转录过程中的作用。TDZD-8也被用于分析其对小鼠嗅球神经功能的影响。
Biochem/physiol Actions
TDZD-8是GSK-3的一种选择性抑制剂、一种酰二唑烷酮衍生物、GSK-3β的一种非ATP竞争性抑制剂（IC50 = 2 μM）。它在>100 μM时不会抑制Cdk-1/cyclin B、CK-II、PKA或PKC。TDZD-8已被提出会与GSK-3β的激酶位点结合。
TDZD-8是GSK-3的一种选择性抑制剂。
Preparation Note
TDZD-8以大于10 mg/ml的浓度溶于DMSO。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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