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Merck
CN

T4626

Sigma-Aldrich

Nα-p甲苯磺酰基-L-精氨酸甲酯 盐酸盐

≥98% (TLC), suitable for ligand binding assays

别名:

TAME 盐酸盐

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About This Item

线性分子式:
H2NC(=NH)NH(CH2)3CH(NHSO2C6H4CH3)CO2CH3 · HCl
CAS号:
分子量:
378.87
Beilstein:
3922357
EC 号:
MDL编号:
UNSPSC代码:
12352103
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

product name

Nα-p甲苯磺酰基-L-精氨酸甲酯 盐酸盐,

检测方案

≥98% (TLC)

质量水平

形式

powder

技术

ligand binding assay: suitable

颜色

white

mp

145-147 (lit.)

储存温度

−20°C

SMILES字符串

Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1

InChI key

JIQFFACVQXXHMY-YDALLXLXSA-N

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应用

Nα-甲苯磺酰基-L-精氨酸甲酯盐酸盐已被用作酯水解底物,用于评估中肠提取物中胰蛋白酶样活性。它也已被用作测定胰酶和人肠样品中胰蛋白酶活性的底物。

生化/生理作用

Nα-对甲苯磺酰基-L-精氨酸甲酯(TAME)与后期促进复合物(APC)结合并阻止其被Cdc20和Cdh1激活。

底物

胰蛋白酶、凝血酶、纤溶酶和其他蛋白酶的底物。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Sappasith Klomklao et al.
Journal of agricultural and food chemistry, 54(15), 5617-5622 (2006-07-20)
Trypsin from tongol tuna (Thunnus tonggol) spleen was purified to 402-fold by ammonium sulfate precipitation, followed by a series of chromatographic separations. The molecular mass of trypsin was estimated to be 24 kDa by size-exclusion chromatography and sodium dodecyl sulfate-polyacrylamide
Xing Zeng et al.
Cancer cell, 18(4), 382-395 (2010-10-19)
Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the spindle assembly checkpoint (SAC), which, in turn, inhibits the ubiquitin ligase activity of the anaphase-promoting complex (APC). Here, we report a small molecule, tosyl-L-arginine methyl ester (TAME)
In vitro digestibility of goat milk and kefir with a new standardised static digestion method (INFOGEST cost action) and bioactivities of the resultant peptides
El SN, et al.
Food & Function, 6(7), 2322-2330 (2015)
Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones
Choudhury A, et al.
Gastroenterology, 111(5), 1313-1320 (1996)
Rakesh Kumar et al.
Frontiers in physiology, 6, 95-95 (2015-04-16)
Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larvae of P. brassicae also feed prolifically on garden nasturtium (Tropaeolum majus L., of the family Tropaeolaceae). Proteolytic digestion was studied in larvae feeding

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