所有图片(4)
About This Item
经验公式（希尔记法）:
C16H18N3O10PNa
CAS号:
分子量:
466.29
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
产品名称
胸苷5′-单磷酸对硝基苯酯 钠盐, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
water: 50 mg/mL
储存温度
−20°C
SMILES字符串
CC(C(N1)=O)=CN([C@H]2C[C@H](O)[C@@H](COP(O)(OC(C=C3)=CC=C3[N+]([O-])=O)=O)O2)C1=O.[Na]
InChI
1S/C16H18N3O10P.Na.H/c1-9-7-18(16(22)17-15(9)21)14-6-12(20)13(28-14)8-27-30(25,26)29-11-4-2-10(3-5-11)19(23)24;;/h2-5,7,12-14,20H,6,8H2,1H3,(H,25,26)(H,17,21,22);;
InChI key
PHNRUCBIIRECII-UHFFFAOYSA-N
相关类别
应用
胸苷5′-单磷酸对硝基苯酯钠盐已被用作评估磷酸二酯酶活性的底物。它也被用作autotaxin抑制检测中的核苷酸类似物。
生化/生理作用
胸苷5′-单磷酸对硝基苯酯钠盐是5′-核苷酸磷酸二酯酶活性的一种人工底物标记。它也可用作胞外核苷酸焦磷酸酶/磷酸二酯酶（NPP）酶家族成员autotaxin（ATX，NPP2）的底物。
底物
毒磷酸二酯酶的一种灵敏的生色底物。它不会被牛脾脏磷酸二酯酶水解。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Characterization of non-lipid autotaxin inhibitors.
Hoeglund AB, et al.
Bioorganic & Medicinal Chemistry, 18(2), 769-776 (2010)
Paul R Stabach et al.
Clinical and translational science, 14(1), 362-372 (2020-10-17)
Enzyme replacement with ectonucleotide pyrophosphatase phospodiesterase-1 (ENPP1) eliminates mortality in a murine model of the lethal calcification disorder generalized arterial calcification of infancy. We used protein engineering, glycan optimization, and a novel biomanufacturing platform to enhance potency by using a
Soluble NTPDase: an additional system of nucleotide hydrolysis in rat blood serum.
Oses JP, et al.
Life Sciences, 74(26), 3275-3284 (2004)
Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes.
Vuaden FC, et al.
European Journal of Pharmacology, 651(1-3), 212-217 (2011)
Ortal Danino et al.
Rheumatology (Oxford, England), 57(8), 1472-1480 (2018-04-25)
Calcium pyrophosphate deposition (CPPD) is associated with osteoarthritis and is the cause of a common inflammatory articular disease. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (eNPP1) is the major ecto-pyrophosphatase in chondrocytes and cartilage-derived matrix vesicles (MVs). Thus, eNPP1 is a principle contributor to
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