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质量水平
方案
≥98.0%
mp
345-350 °C
溶解性
H2O: slightly soluble
aqueous base: moderately soluble
ethanol: slightly soluble
SMILES字符串
[H]N1C(N(C)C2=C(N(C)C=N2)C1=O)=O
InChI
1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)9-7(13)11(5)2/h3H,1-2H3,(H,9,12,13)
InChI key
YAPQBXQYLJRXSA-UHFFFAOYSA-N
基因信息
human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)
rat ... Adora1(29290)
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一般描述
Theobromine is a methylxanthine alkaloid derivative, highly present in cocoa.
应用
Theobromine has been used:
- to test in behavioural assay
- as a food or dietary supplement
- as a standard for theobromine quantification in brewed coffee samples
生化/生理作用
Phosphosdiesterase inhibitor; weak adenosine receptor antagonist; diuretic; smooth muscle relaxant.
Theobromine possesses antitussive action and might be useful in treating acute and chronic cough. It is a catabolic product of caffeine and shows antioxidant and prooxidant properties.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
制备说明
Theobromine is moderately soluble in aqueous base and is slightly soluble in water and ethanol.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
Murat Iskar et al.
Molecular systems biology, 9, 662-662 (2013-05-02)
In pharmacology, it is crucial to understand the complex biological responses that drugs elicit in the human organism and how well they can be inferred from model organisms. We therefore identified a large set of drug-induced transcriptional modules from genome-wide
Behavioral Analysis of Bitter Taste Perception in Drosophila Larvae
Kim H, et al.
Chemical Senses, 41(1), 85-94 (2016)
Development of a chromatographic low pressure flow injection system: Application to the analysis of methylxanthines in coffee
Santos JR and Antonio OSS Rangel
Analytica Chimica Acta, 715(17), 57-63 (2012)
Theobromine inhibits sensory nerve activation and cough
Usmani OS, et al.
Faseb Journal (2004)
A subset of enteroendocrine cells is activated by amino acids in the Drosophila midgut
Park JH, et al.
Febs Letters (2006)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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