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描述
non-ionic
质量水平
产品线
BioXtra
表单
liquid (clear)
杂质
<0.5% water (Coulometric)
<5 ppm heavy metal
颜色
colorless to light yellow
mp
≤ -100 °C
溶解性
water: soluble 3420 g/L
密度
1.09 g/mL at 25 °C (lit.)
SMILES字符串
O1C(CCC1)COCCO
InChI
1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2
InChI key
CTPDSKVQLSDPLC-UHFFFAOYSA-N
应用
四甘醇 已用于：
- 稀释Dil（1,1′-二十八烷基-3,3,3′3′-四甲基吲哚菁高氯酸盐）以注入受精卵进行Dil标记
- 稀释Dil（1,1′-二十八烷基-3,3,3′3′-四甲基吲哚菁高氯酸盐）和diO（3,3′-二十八烷基氧杂碳菁高氯酸盐）以进行染料/病毒注射
- 稀释聚（丙交酯-co-乙交酯）（PLGA）以制备PLGA/F127溶液
用作溶剂以溶解水不溶性化合物。
生化/生理作用
液体糖原质因其具有很好的弹性，可轻松转化为凝胶体系，用作溶于水不溶性药物的介质。
特点和优势
格列本脲（GBD）的高效增溶剂
注意
请勿与三缩四乙二醇混淆，其有时也称为四甘醇。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
275.0 °F - closed cup
闪点(°C)
135 °C - closed cup
个人防护装备
Eyeshields, Gloves
Saly Galal et al.
Acta pharmaceutica (Zagreb, Croatia), 53(1), 57-64 (2004-02-11)
The ability of liquid and semi-solid matrix (SSM) filling capsule technology to improve the dissolution rate of glibenclamide (GBD) was investigated. Semiquantitative estimation of GBD solubility in various vehicles was carried out. Tetraglycol was found to be the most efficient
Nahla Salah Barakat
AAPS PharmSciTech, 11(3), 1138-1146 (2010-07-24)
In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to develop a suitable gel with bioadhesive property
X F Zhang et al.
Materials science & engineering. C, Materials for biological applications, 32(6), 1654-1663 (2012-08-01)
Poly (lactide-co-glycolide) (PLGA) - Pluronic F127 - glass composites have demonstrated excellent potential, from the perspective of controlled mechanical properties and cytocompatibility, for peripheral nerve regeneration. In addition to controlling the mechanical properties and cytotoxicity for such composite devices, the
S Kehoe et al.
Journal of the mechanical behavior of biomedical materials, 14, 180-185 (2012-10-03)
PLGA/pluronic F127 based nerve guidance conduits (NGCs) for peripheral nerve regeneration offer excellent potential for clinical use. To date, little emphasis has been directed towards the effect of pluronic F127 on their subsequent mechanical properties as a function of degradation
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