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Merck
CN

T3125

四氢叶酸

≥65% (when packaged), powder

别名:

5,6,7,8-四氢蝶酰基-L-谷氨酸, THF

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关于此项目

经验公式（希尔记法）:
C19H23N7O6
化学文摘社编号:
135-16-0
分子量:
445.43
UNSPSC Code:
12352204
NACRES:
NA.51
PubChem Substance ID:
24900106
EC Number:
205-181-1
Beilstein/REAXYS Number:
9238187
MDL number:
MFCD00135583
Form:
powder
Solubility:
0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow
Biological source:
synthetic
Color:
faintly yellow to light brown

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InChI

1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

InChI key

MSTNYGQPCMXVAQ-KIYNQFGBSA-N

SMILES string

NC1=NC2=C(NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1

biological source

synthetic

form

powder

concentration

≥65% (when packaged)

color

faintly yellow to light brown

solubility

0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow

storage temp.

−20°C

Quality Level

200

Application

四氢叶酸也可用作标准品，生成标准曲线用于通过高效液相色谱法(HPLC)定量分析牛奶培养物中嗜热链球菌产生的叶酸类型。它还适用于来自扭脱甲基杆菌(M. extorquens)的叶酸-四氢叶酸连接酶(MeFtfL)的酶活检测。
四氢叶酸已用于测定四氢叶酸对多形核髓源性抑制细胞(PMN-MDSC)的抑制作用。四氢叶酸(THF)最近被用于研究核糖开关的活性。

Biochem/physiol Actions

四氢叶酸是为氨基酸、核酸和脂质提供一碳单位的叶酸盐衍生物的母体分子。四氢叶酸盐代谢物参与嘌呤和嘧啶的合成以及氨基酸的合成和转化

Packaging

密封安瓿瓶。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000496153
0000496153
0000483083
0000483083
0000426528

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Lili Huang et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(36), 14801-14806 (2011-08-30)
Tetrahydrofolate (THF), a biologically active form of the vitamin folate (B(9)), is an essential cofactor in one-carbon transfer reactions. In bacteria, expression of folate-related genes is controlled by feedback modulation in response to specific binding of THF and related compounds
Ronald R Breaker
Molecular cell, 43(6), 867-879 (2011-09-20)
An expanding number of metabolite-binding riboswitch classes are being discovered in the noncoding portions of bacterial genomes. Findings over the last decade indicate that bacteria commonly use these RNA genetic elements as regulators of metabolic pathways and as mediators of
Susanne H Kirsch et al.
Analytical and bioanalytical chemistry, 404(3), 895-902 (2012-06-26)
Folates act as essential coenzymes in many biological pathways, including the synthesis and methylation of DNA. Low folate concentration in serum and whole blood (WB) is associated with several disease conditions. We describe a stable-isotope-dilution ultra performance liquid chromatography tandem
Daniela Sumczynski et al.
Food chemistry, 264, 386-392 (2018-06-02)
Non-traditional wild rice flakes were analysed for chemical composition, vitamin B compounds, α-tocopherol, mineral and trace elements. Dietary intakes of vitamins, minerals and trace elements were evaluated using FAO/WHO and Institute of Medicine regulations. Wild rice flakes proved to be
Francisco García-Molina et al.
Journal of agricultural and food chemistry, 59(4), 1383-1391 (2011-01-27)
The coenzyme tetrahydrofolic acid is the most rapid suicide substrate of tyrosinase that has been characterized to date. A kinetic study of the suicide inactivation process provides the kinetic constants that characterize it: λ(max), the maximum apparent inactivation constant; r
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