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T2386

Sigma-Aldrich

Δ9-四氢大麻酚 溶液

ethanol solution

别名:

Δ1-四氢大麻醇

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About This Item

经验公式（希尔记法）:
C21H30O2
CAS号:
1972-08-3
分子量:
314.46
MDL编号:
MFCD00083207
UNSPSC代码:
12352200
PubChem化学物质编号:
24900035
NACRES:
NA.77

形式

ethanol solution

质量水平

200

药品控制

USDEA Schedule I; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

浓度

25 mg/mL (+/- 5%)

储存温度

−20°C

SMILES字符串

[H][C@@]12CCC(C)=C[C@@]1([H])c3c(O)cc(CCCCC)cc3OC2(C)C

InChI

1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1

InChI key

CYQFCXCEBYINGO-IAGOWNOFSA-N

基因信息

human ... CNR1(1268) , CNR2(1269)
mouse ... Cnr1(12801)
rat ... Cnr1(25248)

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相关类别

应用

Δ9-tetrahydrocannabinol solution has been used to study its effects on schizophrenia-related behaviors in a developmental mouse model of schizophrenia.

生化/生理作用

Δ9-Tetrahydrocannabinol or Δ9-THC is a psychoactive ingredient in marijuana that is known to function as a neuroprotective antioxidant21. In vivo microdialysis studies have reported that Δ9-THC can enhance extracellular dopamine efflux in the nucleus accumbens of conscious, freely-moving rats22.
Agonist at CB1 and CB2 cannabinoid receptors. Hallucinogen; major psychoactive component of marijuana from Cannabis sativa.

特点和优势

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

Δ9-Tetrahydrocannabinol solution is essentially insoluble in water.

象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险声明

H225,H319

危险分类

Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

闪点(°F)

57.2 °F

闪点(°C)

14 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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Delta9-tetrahydrocannabinol (Delta9-THC) administration after neonatal exposure to phencyclidine potentiates schizophrenia-related behavioral phenotypes in mice.
Rodriguez G, et al.
Pharmacology, Biochemistry, and Behavior, 159, 6-11 (2017)
J P Chen et al.
Psychopharmacology, 102(2), 156-162 (1990-01-01)
This study examined the effects of acute administration of delta-9-tetrahydrocannabinol (delta 9-THC), the psychoactive ingredient in marijuana, on extracellular efflux of dopamine (DA) and its metabolites as measured by in vivo microdialysis in nucleus accumbens of conscious, freely-moving rats. delta
A J Hampson et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(14), 8268-8273 (1998-07-08)
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. Glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic cannabinoid
Nafsika Poulia et al.
British journal of pharmacology, 178(7), 1722-1736 (2021-01-27)
Adolescent cannabis use is associated with adult psychopathology. When Δ9 -tetrahydrocannabinol (THC), mainly in high doses, is administered to adolescence rats there are also long lasting effects in adults. This study aims to determine the specific adult bio-behavioural profile after
S Ameur et al.
Analytical and bioanalytical chemistry, 405(10), 3117-3123 (2013-01-29)
A cloud point extraction coupled with high performance liquid chromatography (HPLC/UV) method was developed for the determination of Δ(9)-tetrahydrocannabinol (THC) in micellar phase. The nonionic surfactant "Dowfax 20B102" was used to extract and pre-concentrate THC from cannabis resin, prior to
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