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Merck
CN
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文件

T0266

Sigma-Aldrich

牛磺酸脱氧胆酸钠

别名:

3α,7β-二羟基-5β-胆烷-24-羧酸-N-（2-磺乙基）酰胺, 牛磺熊去氧胆酸 钠盐

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About This Item

线性分子式:
C26H44NO6SNa
CAS号:
35807-85-3
分子量:
521.69
MDL编号:
MFCD00065451
UNSPSC代码:
12161900
PubChem化学物质编号:
24899875
NACRES:
NA.25

描述

anionic

质量水平

200

检测方案

≥95.0% (TLC)

分子量

521.69 g/mol

CMC

4

HLB

20.1

SMILES字符串

[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCCS(=O)([O-])=O)=O.[Na+]

InChI

1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1

InChI key

BHTRKEVKTKCXOH-LBSADWJPSA-N

相关类别

一般描述

牛磺熊去氧胆酸钠是一种胆汁盐，天然存在于小肠中。

应用

牛磺熊去氧胆酸钠已被用于评估ER应激是否与棕榈酸上调（PA）有关。 它还被用于研究其对雌性大鼠雌二醇-17β-D-葡糖苷酸（E-17G）诱导的胆汁淤积的影响。

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Ana F Nunes et al.
Molecular neurobiology, 45(3), 440-454 (2012-03-23)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid-β (Aβ) peptide in the hippocampus and frontal cortex of the brain, leading to progressive cognitive decline. The endogenous bile acid tauroursodeoxycholic acid (TUDCA) is a strong neuroprotective agent
Junichi Ishiyama et al.
Journal of lipid research, 52(2), 299-307 (2010-11-17)
Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is known to induce endoplasmic reticulum
Laura Obici et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 19 Suppl 1, 34-36 (2012-05-04)
We designed a phase II, open-label study to evaluate the efficacy, tolerability, safety, and pharmacokinetics of orally doxycycline (100 mg BID) and tauroursodeoxycholic acid (TUDCA) (250 mg three times/day) administered continuously for 12 months. Primary endpoint is response rate defined
Jianbo Fu et al.
The Journal of toxicological sciences, 41(6), 745-756 (2016-11-18)
2,4-Dichlorophenol (2,4-DCP) is an environmental pollutant exhibiting a wide spectrum of toxic effects. We investigated the toxic effects and potential mechanisms underlying 2,4-DCP-induced hepatotoxicity. In vitro, 2,4-DCP caused hepatotoxicity manifested by a decrease in cell viability and inhibition of colony
S Kinbara et al.
Scandinavian journal of gastroenterology, 32(9), 947-952 (1997-09-23)
Estradiol-17 beta-D-glucuronide (E-17G), a metabolite of natural estrogen, is well known to cause intrahepatic cholestasis in humans. We therefore investigated the effect of sodium tauroursodeoxycholate (T-UDCA), on E-17G-induced cholestasis in female rats. For the evaluation of the drug, animals given
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