T0203
TGFβR2 (190-端)，活性，GST 标记 人
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
AAT3, FAA3, HPNCC6, MFS2, RIIC, TAAD2, TGFR-2
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
buffered aqueous glycerol solution
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
~68 kDa
产品名称
TGFβR2 (190-端)，活性，GST 标记 人, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
6-8 nmol/min·mg
mol wt
~68 kDa
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... TGFBR2(7048)
Biochem/physiol Actions
Transforming growth factor β receptor 2 (TGFBR2)-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses. The TGFBR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-β type II receptor. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and the development of various types of tumors.
General description
Transforming growth factor β receptor 2 (TGFBR2) is a member of the TGFβ receptor subfamily and is a serine/threonine protein kinase. The gene encoding this protein is localized on human chromosome 3p24.1.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells
Fabia Fricke
Cell communication and signaling : CCS (2017)
Loeys?Dietz syndrome: a primer for diagnosis and management
Gretchen
Genitourinary Medicine null
Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing
Michael T
PLoS ONE (2017)
Arthrogryposis as neonatal presentation of Loeys-Dietz syndrome due to a novel TGFBR2 mutation.
Valenzuela I
European Journal of Medical Genetics (2017)
Heterozygous TGFBR2 mutations in Marfan syndrome
Takeshi Mizuguchi
Nature Genetics (2004)
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