推荐产品
生物来源
human
重组
expressed in mammalian cells
检测方案
≥95% (HPLC)
≥95% (SDS-PAGE)
形式
lyophilized
分子量
26.9 kDa
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... GZMA(3001)
一般描述
Granzyme A is a member of the granzyme family. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Human granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1-26), a propeptide (residues 27-28) and a mature chain (residues 29-262).
外形
Lyophilized from a 0.2 μm filtered solution of 20 mM MES and150 mM NaCl, pH 5.5.
制备说明
Centrifuge the vial prior to opening.
重悬
Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). This can further be diluted to other aqueous buffers.
其他说明
Recombinant Human Granzyme A is produced with mammalian cells expression system. Target protein is expressed with sequence (Glu27-Val262) of Human granzyme a (Uniprot #P12544) fused with a polyhistidine tag at the C-terminus.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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Experimental eye research, 134, 1-14 (2015-03-11)
Recently, thrombospondin-1 (TSP-1) has been reported to be critical for maintaining a healthy ocular surface. The purpose of the study was to characterize the expression of TSP-1 and of its receptors CD36 and CD47 in corneal and conjunctival epithelial cells
Sung Min Son et al.
Neurobiology of aging, 36(12), 3214-3227 (2015-10-11)
Alzheimer's disease (AD) is characterized by impaired cognitive function and memory loss, which are often the result of synaptic pathology. Thrombospondin (TSP) is an astrocyte-secreted protein, well known for its function as a modulator of synaptogenesis and neurogenesis. Here, we
Sehwon Koh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15649-15665 (2015-11-27)
Cell therapy demonstrates great potential for the treatment of neurological disorders. Human umbilical tissue-derived cells (hUTCs) were previously shown to have protective and regenerative effects in animal models of stroke and retinal degeneration, but the underlying therapeutic mechanisms are unknown.
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