推荐产品
生物来源
human
重组
expressed in E. coli
方案
≥95% (HPLC)
≥95% (SDS-PAGE)
表单
lyophilized
分子量
~17.2 kDa
包装
pkg of 50 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FGF2(2247)
相关类别
一般描述
The gene FGF2 (fibroblast growth factor 2) is mapped to human chromosome 4q28. FGF-2 is a basic heparin binding growth factor. The recombinant human FGF-2 is a 17.2kDa protein containing 154 amino acid residues. It is also referred to as BFGF (basic fibroblast growth factor).
应用
FGF-2 human has been used:
- as medium supplement for E9.5 neuroepithelial cell culture
- as a component in the neurobasal growth medium
- in growing embryonic neural stem/progenitor cells (NSPCs) in a 2D culture
FGF2 (fibroblast growth factor 2)-human has been used in endothelial colony assay.
生化/生理作用
FGF2 (fibroblast growth factor 2, also referred to as BFGF (basic fibroblast growth factor)) interacts with FGFR1 (fibroblast growth factor receptor 1), FGFR2 and FGFR3. It stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. FGF2 also determines the fate of neural precursor cells and promotes neuronal axon regeneration. It plays an important role in spinal cord injury repair. FGF2 is known to stimulate angiogenesis and is associated with cancer development. High levels of FGF2 are present in the kidney of children with HIV (human immunodeficiency virus)-renal diseases. The FGF2 mRNA is a target of miRNA miR-503.
外形
Lyophilized from a 1 mg/ml solution of 5 mM Tris pH 7.6 plus 150 mM NaCl.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 5 mM Tris, pH 7.6 to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
胰岛素激素类产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation
Li H, et al.
Development, 145(24), dev169797-dev169797 (2018)
Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors.
Peichev M
Blood, 95, 952-958 (2000)
Isolation of Neural Stem Cells from the Embryonic Mouse Hippocampus for in vitro Growth or Engraftment into a Host Tissue
Rybachuk O, et al.
Bio-protocol, 9(4) (2019)
Role of microRNA?503 in the suppression of osteosarcoma cell proliferation and migration via modulation of fibroblast growth factor 2.
Wu B and Bi W
Molecular Medicine Reports, 12, 7433-7438 (2015)
Yang Hu et al.
Molecular medicine reports, 13(1), 49-58 (2015-11-18)
Recent studies regarding regenerative medicine have focused on bone marrow mesenchymal stem cells (BMSCs), which have the potential to undergo neural differentiation, and may be transfected with specific genes. BMSCs can differentiate into neuron‑like cells in certain neurotropic circumstances in
商品
可生成组织和干细胞来源3D脑、胃肠道、肺和癌症肿瘤类器官模型的类器官培养产品。
Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门