产品名称
EGF 来源于小鼠, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
0.1 ng/mL
mol wt
6.0 kDa
packaging
pkg of 500 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
off-white to yellow
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... EGF(13645)
Application
来自小鼠的 EGF 也用于 DMEM/F12 培养基中培养小鼠肾细胞。
Biochem/physiol Actions
表皮生长因子 (EGF) 具有抑制胃液分泌、促进伤口愈合的作用。 EGF 通过一种称为 c-erbB 的受体传递信号，c-erbB 是一类酪氨酸激酶受体。该受体还与 TGF（转化生长因子）-α和 VGF（牛痘病毒生长因子）结合。EGF 在胚胎发生和心脏发生中起重要角色。
General description
EGF (epidermal growth factor) 是一种强效的生长因子，能刺激多种表皮和上皮细胞的增殖。重组鼠 EGF 是一种 6 kDa 的球状蛋白，含有 53 个氨基酸残基，包括 3 个分子内二硫键。
Other Notes
NSYPGCPSSY DGYCLNGGVC MHIESLDSYT CNCVIGYSGD RCQTRDLRWW ELR
Physical form
从 10 mM 磷酸钠 (pH 8.2) 冻干。
Preparation Note
打开前离心小瓶。用水复溶至 0.5-1.0 mg/mL 浓度。切勿涡旋。该溶液可在 2-8°C 条件下至多储存 1 周。为了延长储存时间，建议在含有载体蛋白（例如 0.1%BSA）的缓冲液中进一步稀释，并在-20°C 至-80°C 下储存。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Requirement of Leukemia Inhibitory Factor or Epidermal Growth Factor for Pre-Implantation Embryogenesis via JAK/STAT3 Signaling Pathways.
Cheng EH
PLoS ONE, 11, e0153086-e0153086 (2016)
EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner.
Ma CX
Cellular and Molecular Life Sciences, 72, 2005-2022 (2015)
Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease.
Menezes LF
EBioMedicine, 5, 183-192 (2016)
Reactive oxygen species (ROS) are essential mediators in epidermal growth factor (EGF)-stimulated corneal epithelial cell proliferation, adhesion, migration, and wound healing.
Huo Y
Experimental Eye Research, 89, 876-886 (2009)
Epidermal growth factor therapy and wound healing--past, present and future perspectives.
Hardwicke J
The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 6, 172-177 (2008)
商品
Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.
可生成组织和干细胞来源3D脑、胃肠道、肺和癌症肿瘤类器官模型的类器官培养产品。
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