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Merck
CN
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主要文件

安全信息

SRP2036

Sigma-Aldrich

BRG1, wild type human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

别名:

BAF190, BRG1, FLJ39786, RTPS2, SNF2, SNF2-beta, SNF2L4, SNF2LB, SWI2, hSNF2b

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About This Item

UNSPSC代码:
12352200
NACRES:
NA.26

生物来源

human

重组

expressed in insect cells

方案

≥80% (SDS-PAGE)

表单

frozen liquid

分子量

~185 kDa

包装

pkg of 5 μg

储存条件

avoid repeated freeze/thaw cycles

浓度

300 μg/mL

颜色

clear
colorless

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−70°C

基因信息

human ... SMARCA4(6597)

生化/生理作用

The wild type human brahma-related gene 1 (Brg1) encodes a protein of 1,647 amino acids that contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription regulation. BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Although Brg1 is involved in chromatin remodeling as a complex with other SWI/SNF proteins, purified BRG1 itself is capable of remodeling mono-nucleosomes and nucleosomal arrays in vitro. Mutations of Brg1 have been found in multiple tumor cell lines.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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P A Khavari et al.
Nature, 366(6451), 170-174 (1993-11-11)
Sequence-specific DNA binding activators of gene transcription may be assisted by SWI2 (SNF2), which contains a DNA-dependent ATPase domain. We have isolated a human complementary DNA encoding a 205K nuclear protein, BRG1, that contains extensive homology to SWI2 and Drosophila
S Sif et al.
Genes & development, 12(18), 2842-2851 (1998-09-23)
During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed by the chromatin remodeling activity of the SWI/SNF complexes. Brg1 and hBrm, which are components of human SWI/SNF (hSWI/SNF) complexes, were recently shown
C J Fryer et al.
Nature, 393(6680), 88-91 (1998-05-20)
The assembly of transcriptional regulatory DNA sequences into chromatin plays a fundamental role in modulating gene expression. The promoter of the mouse mammary-tumour virus (MMTV) is packaged into a regular array of nucleosomes when it becomes stably integrated into mammalian

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