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Merck
CN

SML1495

Sigma-Aldrich

舒洛芬(Suprofen)

≥98% (HPLC)

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别名:
(±)-Suprofen, 2-[4-(Thiophene-2-carbonyl)phenyl]propanoic acid, NSC 303611, p-(2-Thenoyl)hydratropic acid, α-Methyl-p-(2-thenoyl)phenylacetic acid
经验公式(希尔记法):
C14H12O3S
CAS号:
分子量:
260.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

room temp

SMILES字符串

CC(C(O)=O)c1ccc(cc1)C(=O)c2cccs2

InChI

1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)

InChI key

MDKGKXOCJGEUJW-UHFFFAOYSA-N

基因信息

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应用

Suprofen has been used to evaluate the combination of trifluoroacetic acid and isopropylamine (IPA) in supercritical fluid chromatography. It has also been used to evaluate immobilized chiral polysaccharide-based stationary phases in supercritical fluid chromatography.

生化/生理作用

Suprofen is a nonsteroidal anti-inflammatory drug that inhibits COX-1/2. Suprofen exhibits a potent anti-inflammatory, analgesic and antipyretic activities.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Pharmaceutical-enantiomers resolution using immobilized polysaccharide-based chiral stationary phases in supercritical fluid chromatography
De Klerck
Journal of Chromatography A (2014)
A S Nies
Agents and actions. Supplements, 24, 95-106 (1988-01-01)
All nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase, and consequently renal functions dependent upon prostaglandin synthesis can be affected. Fortunately, renal function in normal individuals is relatively independent of the PG system, and thus the NSAIDs don't usually produce any renal
C J Niemegeers et al.
Arzneimittel-Forschung, 25(10), 1505-1509 (1975-10-01)
A new standardized acetic acid-induced writhing test in rats is described in detail and its methodology is discussed briefly. The described method has proved to be useful for evaluating the anti-writhing activity of narcotic analgesics, non-narcotic anti-inflammatory compounds and narcotic-antagonists
Combined use of isopropylamine and trifluoroacetic acid in methanol-containing mobile phases for chiral supercritical fluid chromatography
De Klerck, Katrijn, et al
Journal of Chromatography A, 72-79 (2012)
E L Tolman et al.
Clinics in rheumatic diseases, 10(2), 353-368 (1984-08-01)
Suprofen is a potent, peripherally-acting, non-narcotic analgesic agent. The mechanism of action of the compound involves inhibition of prostaglandin biosynthesis and, perhaps, direct antagonism of the peripheral, pain inducing actions of prostaglandins, bradykinin and other pain mediators. Suprofen at a

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