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Merck
CN

SML0861

Sigma-Aldrich

A-484954

≥98% (HPLC)

别名:

7-氨基-1-环丙基-3-乙基-1,2,3,4-四氢-2,4-二氧代-吡啶 \ [2,3-d] 嘧啶-6-甲酰胺, A484954

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About This Item

经验公式(希尔记法):
C13H15N5O3
分子量:
289.29
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 3 mg/mL, clear (warmed)

储存温度

2-8°C

InChI

1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19)

InChI key

HWODCHXORCTEGU-UHFFFAOYSA-N

应用

A-484954已被用作选择性和强效抑制剂来抑制eEF2K(真核伸长因子2激酶),以检查海马CA1区放射状层中突触传递的增强。它也已用作eEF2K 抑制剂来监测U2OS Arntl::dLUC 细胞的实时发光。

生化/生理作用

A-484954是一种有效、选择性的真核伸长因子2激酶 (eEF2K)抑制剂。蛋白质合成所需的真核伸长因子-2在被eEF2K磷酸化后被灭活。

特点和优势

《受体分类和信号转导》手册的 Ca/CaMKs 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms
Weng W, et al.
Frontiers in Cellular Neuroscience, 10, 247-247 (2016)
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Walton Z E, et al.
Cell (2018)
Kanzo Suzuki et al.
Cell reports, 37(5), 109918-109918 (2021-11-04)
Ketamine is a noncompetitive glutamatergic N-methyl-d-aspartate receptor (NMDAR) antagonist that exerts rapid antidepressant effects. Preclinical studies identify eukaryotic elongation factor 2 kinase (eEF2K) signaling as essential for the rapid antidepressant action of ketamine. Here, we combine genetic, electrophysiological, and pharmacological
Zandra E Walton et al.
Cell, 174(1), 72-87 (2018-06-05)
Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes. Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify

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